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Purpose: To describe and report the neuroradiological findings and clinicalKey words: Brain, familial features in a patient with familial haemophagocytic lymphohistocytosis (FHL), haemophagocytic a rare hereditary immune dysregulation in early childhood characterised by lymphohistocytosis; Epstein-Barr multisystem involvement, including in approximately 30% of cases also the cen-virus; MR imaging, paediatric. tral nervous system (CNS).Material and Methods: Serial brain MR examinations were carried out in a Correspondence: Pia Sundgren, 4.5-year-old boy with FHL, finally complicated with Epstein-Barr virus (EBV)-Division of Neuroradiology, driven posttransplantation lymphoma.Department of Diagnostic Results: Multiple brain MR examinations before and after contrast enhance-Radiology, University Hospital, ment showed discrete perivascular non-enhancing areas of high signal intensity SE-221 85 Lund, Sweden. on T2 images, and later also an enhancing lesion in the right caudate nucleus.FAX π46 46 12 18 37. Conclusion: FHL should be included in the differential diagnosis of patchy white matter abnormalities in young patients. EBV-driven post-transplantation Accepted for publication 17 June lymphoma, which may present as meningial and/or parenchymal CNS infil-1999. tration, is a differential diagnostic problem.

Pituitary basic and neuroendocrinology• Thirty-four (21 women) ALL survivors, on complete hormone supplementation • 34 years after ALL diagnosis.• Median-age: 38 (27-46) years • CRT dose of 24 Gy.• Comparison was made with 31 matched controls.Conclusion ALL women treated with CRT are at high risk of metabolic abnormalities in association with a smaller HT volume 34 years after ALL diagnosis. These findings suggest an hypothalamic effect of the metabolic complications.Background:There is an increased risk for metabolic complications in ALL survivors treated with cranial radiotherapy (CRT). These complications include obesity, lipid abnormalities, insulin resistance and the etiology is not well understood. The hypothalamus (HT) is a small complex area of the brain involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, an orexigenic peptide stimulating food intake, has not been performed previously.

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