Adverse Reactions in Myelography: Correlation between Animal Research and Clinical Practice

Maly, Pavel; Sundgren, Pia; Bååth, Lars B.; Golman, C; Walday, Per

doi:10.1177/0284185195036s39928

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…These rabbits received a 53% smaller number of iodixanol molecules than rabbits injected with iodixanol 320 mg 11m!' A similar dose response relationship has been shown in a subsequent study (12).…”

Section: Discussionsupporting

confidence: 86%

“…This previously known relatively marked excitative effect of iotrolan in rabbits (1) was also confirmed in a subsequent study in which 8/10 rabbits developed generalised seizures (12). The non-ionic monomer iopamidol, another contrast medium which is considered clinically safe for both intrathecal and intravascular administration, has been shown to produce a moderate excitative effect comparable to that of iodixanol in the same animal model, in both previous and subsequent studies (5,12).…”

Section: Discussionmentioning

confidence: 59%

“…induced seizures in 2/10 and 1/ 10 rabbits, respectively, regarded as a moderate excitative effect. A somewhat weaker excitative effect, without seizures, was also observed in a subsequent experiment (12). The reason for the difference between the total absence of excitative effect in 17 rabbits injected with the experimental preparation of iodixanol in a previous experiment (1), and the effects produced by its commercial preparations used now and in the subsequent experiment (12), is not known.…”

Section: Discussionmentioning

confidence: 85%

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CNS-Effects from Subarachnoid Injections of Iohexol and the Non-Ionic Dimers Iodixanol and Iotrolan in the Rabbit

Sundgren

Bååth²,

Maly³

1995

Acta Radiol

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The neural tolerance of the new non-ionic dimer iodixanol was compared with that of the clinically used monomer iohexol and the dimer iotrolan. Behaviour of non-anaesthetised rabbits was monitored for 3 hours after intracisternal injection, at a dose-volume of I ml/kg of iodixanol 150 mg IIml, iodixanol 320 mg IIml, iohexol 350 mg IIml, or iotrolan 300 mg IIml (10 rabbits in each group). Iotrolan induced generalised seizures in 5 rabbits, iodixanol 320 mg IIml in 2 rabbits, and iodixanol 150 mg IIml in one rabbit. No excitative changes were observed in rabbits injected with iohexol, but compared with the dimeric contrast media the difference was not significant. Iohexol produced significantly more severe depressive changes than iodixanol 150 mg IIml (p

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 85%

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CNS-Effects from Subarachnoid Injections of Iohexol and the Non-Ionic Dimers Iodixanol and Iotrolan in the Rabbit

Sundgren

Bååth²,

Maly³

1995

Acta Radiol

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Technical Note: A custom‐designed flexible MR coil array for spine radiotherapy treatment planning

Tyagi

Zakian

Italiaander³

et al. 2020

Medical Physics

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To assess the performance and optimize the MR image quality when using a custom-built flexible radiofrequency (RF) spine coil array fitted between the immobilization device and the patient for spine radiotherapy treatment planning. Methods: A 32 channel flexible custom-designed receive-only coil array has been developed for spine radiotherapy simulation for a 3 T Philips MR scanner. Coil signal-to-noise performance and interactions with standard vendor hardware were assessed. In four volunteers, immobilization molds were created with a dummy version of the array within the mold, and subjects were scanned using the custom array in the mold. Phantoms and normal volunteers were scanned with both the custom spine coil array and the vendor's FDA-approved in-table posterior coil array to compare performance. Results: The superior-inferior field of view for the custom spine array was~30 cm encompassing at least 10 vertebrae. A noise correlation matrix showed at least 25 dB isolation between all coil elements. Signal-to-noise ratio (SNR) calculated on a phantom scan at the depth of the spinal cord was a factor of 3 higher with the form-fit spine array as compared to the vendor's posterior coil array. The body coil B 1 transmit map was equivalent with and without the spine array in place demonstrating that the elements are decoupled from the body coil. Volunteer imaging showed improved SNR as compared to the vendor's posterior coil array. The custom array permitted a high degree of acceleration making possible the acquisition of isotropic high-resolution 1.1 9 1.1 9 1.1 mm 3 three-dimensional data set over a 30-cm section of the spine in less than 5 min. Conclusion:The custom-designed form-fitting flexible spine coil array provided enhanced SNR and increased acceleration compared to the vendor's posterior array. Future studies will assess MR-based spinal cord imaging with the custom coil in comparison to CT myelogram.

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Preclinical safety assessment of contrast media: predictive value

Karlsson

1996

Eur. Radiol.

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The purpose of preclinical tests is to identify the potential benefits and risks of new diagnostic or therapeutic products. Regarding iodinated contrast media (CM), LD50 tests were used extensively in the past. However, from both scientific and ethical perspectives, it is today highly relevant to question the use of LD50 tests. Due to species differences and the very high volume of CM needed to kill half of the animals, such tests are not sensitive enough to differentiate between modern nonionic CM. Further, they are not very predictive in terms of human tolerability. In other tests with more relevant end-points than death, overall tolerance to the new dimeric compound iodixanol (Visipaque), representing the latest step in the development of CM, has been shown to be higher than to the nonionic monomers. Clinical experience has shown that the physiological parameters often stay closer to baseline after Visipaque than after administration of conventional CM.

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Adverse Reactions in Myelography: Correlation between Animal Research and Clinical Practice

Cited by 5 publications

References 48 publications

CNS-Effects from Subarachnoid Injections of Iohexol and the Non-Ionic Dimers Iodixanol and Iotrolan in the Rabbit

CNS-Effects from Subarachnoid Injections of Iohexol and the Non-Ionic Dimers Iodixanol and Iotrolan in the Rabbit

Technical Note: A custom‐designed flexible MR coil array for spine radiotherapy treatment planning

Preclinical safety assessment of contrast media: predictive value

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