A 3-week course of 4 mg/kg AmBisome resulted in a significantly earlier CSF culture conversion than 0.7 mg/kg amphotericin B, had equal clinical efficacy and was significantly less nephrotoxic when used for the treatment of primary episodes of AIDS-associated cryptococcal meningitis.

No abstract

The German language USS-PROM shows similar psychometric properties to the English language version. This instrument can be improved by assessing EF by the use of IIEF-5. Further studies with larger patient cohorts are needed to evaluate the significance of measuring UI in urethroplasty patients.

Time is among the most important yet mysterious aspects of experience. We investigated everyday mental time travel, especially into the future. Two community samples, contacted at random points for 3 (Study 1; 6,686 reports) and 14 days (Study 2; 2,361 reports), reported on their most recent thought. Both studies found that thoughts about the present were frequent, thoughts about the future also were common, whereas thoughts about the past were rare. Thoughts about the present were on average highly happy and pleasant but low in meaningfulness. Pragmatic prospection (thoughts preparing for action) was evident in thoughts about planning and goals. Thoughts with no time aspect were lower in sociality and experiential richness. Thoughts about the past were relatively unpleasant and involuntary. Subjective experiences of thinking about past and future often were similar—while both differed from present focus, consistent with views that memory and prospection use similar mental structures.