COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million people with a toll of 0.75 million deaths and restricting the movement of most of the world population during the past 6 months. COVID-19 became the leading health, economic, and humanitarian challenge of the twenty-first century. In addition to the considerable COVID-19 cases, hospitalizations, and deaths in humans, several cases of SARS-CoV-2 infections in animal hosts (dog, cat, tiger, lion, and mink) have been reported. Thus, the concern of pet owners is increasing. Moreover, the dynamics of the disease requires further explanation, mainly concerning the transmission of the virus from humans to animals and vice versa. Therefore, this study aimed to gather information about the reported cases of COVID-19 transmission in animals through a literary review of works published in scientific journals and perform genomic and phylogenetic analyses of SARS-CoV-2 isolated from animal hosts. Although many instances of transmission of the SARS-CoV-2 have been reported, caution and further studies are necessary to avoid the occurrence of maltreatment in animals, and to achieve a better understanding of the dynamics of the disease in the environment, humans, and animals. Future research in the animal–human interface can help formulate and implement preventive measures to combat the further transmission of COVID-19.

(ICTV) adotou síndrome respiratória aguda grave 2 (SARS-CoV-2) como nome para o novo vírus causador da COVID-19. O presente trabalho objetivou reunir informação sobre a possível origem do novo coronavírus (SARS-CoV-2). Realizou-se uma revisão de literária de trabalhos nacionais e internacionais publicados em revistas científicas eletrônicas e impressas, acessíveis através da web, além de livros. Estudos aponta que SARS-CoV-2 seja um vírus quimérico entre um coronavírus de morcego e um coronavírus de origem desconhecida. Uma das possibilidades aponta para o morcego sendo reservatório da SARS-CoV-2, transmitindo ao homem via pangolim. Pangolim-CoV é 91,02% e 90,55% idêntico ao SARS-CoV-2 e BatCoV RaTG13. Logo, é improvável que a origem do SARS-CoV-2 seja artificial, por manipulação laboratorial. Entretanto, ainda que remota, são necessárias maiores investigações para que se possa descartar uma provável liberação do SARS-CoV-2.

Background The new coronavirus, named the severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). COVID-19 originated in China and spread to other countries and continents causing a variety of respiratory and non-respiratory symptoms that led to death in severe cases. Scope and approach In this review, we discuss and analyze the impact of the COVID-19 pandemic on animal production systems and food products including meat, dairy, eggs, and processed food, in addition to assessing the pandemic's impact on animal health care systems, animal health care quality, animal welfare, food chain sustainability, and the global economy. We also provide effective recommendations to animal producers, veterinary healthcare professionals, workers in animal products industries, and governments to alleviate the effects of the pandemic on livestock farming and production systems. Key findings and conclusions Port restrictions, border restrictions, curfews, and social distancing limitations led to reduced quality, productivity, and competitiveness of key productive sectors. The restrictions have hit the livestock sector hard by disrupting the animal feed supply chain, reducing animal farming services, limiting animal health services including delays in diagnosis and treatment of diseases, limiting access to markets and consumers, and reducing labor-force participation. The inhumane culling of animals jeopardized animal welfare. Egg smashing, milk dumping, and other animal product disruptions negatively impacted food production, consumption, and access to food originating from animals. In summary, COVID-triggered lockdowns and limitations on local and international trade have taken their toll on food production, animal production, and animal health and welfare. COVID-19 reverberations could exacerbate food insecurity, hunger, and global poverty. The effects could be massive on the most vulnerable populations and the poorest nations.

A new virus, classified as a variant of the coronavirus that causes severe acute respiratory syndrome (SARS), is severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2. The virus can be inactivated by heating at 56 ºC for 30 minutes and by using lipid solvents such as ethanol (> 75%), isopropanol (> 70%), formaldehyde (> 0.7%), povidone iodine (> 0, 23%), sodium hypochlorite (> 0.21%), or hydrogen peroxide (> 0.5%), but not chlorhexidine. Another approach is to use a footbath at the entrance of a house. The use of irradiation with ultraviolet light for 60 minutes resulted in the inactivation of several coronaviruses.

Population growth and industrialization have led to a race for greater food and supply productivity. As a result, the occupation and population of forest areas, contact with wildlife and their respective parasites and vectors, the trafficking and consumption of wildlife, the pollution of water sources, and the accumulation of waste occur more frequently. Concurrently, the agricultural and livestock production for human consumption has accelerated, often in a disorderly way, leading to the deforestation of areas that are essential for the planet’s climatic and ecological balance. The effects of human actions on other ecosystems such as the marine ecosystem cause equally serious damage, such as the pollution of this habitat, and the reduction of the supply of fish and other animals, causing the coastal population to move to the continent. The sum of these factors leads to an increase in the demands such as housing, basic sanitation, and medical assistance, making these populations underserved and vulnerable to the effects of global warming and to the emergence of emerging and re-emerging diseases. In this article, we discuss the anthropic actions such as climate changes, urbanization, deforestation, the trafficking and eating of wild animals, as well as unsustainable agricultural intensification which are drivers for emerging and re-emerging of zoonotic pathogens such as viral (Ebola virus, hantaviruses, Hendravirus, Nipah virus, rabies, and severe acute respiratory syndrome coronavirus disease-2), bacterial (leptospirosis, Lyme borreliosis, and tuberculosis), parasitic (leishmaniasis) and fungal pathogens, which pose a substantial threat to the global community. Finally, we shed light on the urgent demand for the implementation of the One Health concept as a collaborative global approach to raise awareness and educate people about the science behind and the battle against zoonotic pathogens to mitigate the threat for both humans and animals.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.

O presente estudo buscou apresentar o perfil epidemiológico dos casos notificados no município de Primavera do Leste, Mato Grosso, entre os anos de 2002 a 2012, a partir de dados registrados nos sistemas de informação oficial de notificações do país: DATASUS e SINAN. Durante o período avaliado foram notificados 3548 casos, havendo mais frequência nas áreas urbanas, em mulheres, assim como indivíduos das raças parda e branca, nas faixas etárias entre 20 a 39 anos, com ensino Fundamental completo e incompleto. Dengue clássica registrou a maioria das ocorrências, o que refleti na evolução da maioria dos casos para cura sem sequelas. Os óbitos se deram pelo agravo da notificação que correram devido a Febre Hemorrágica do Dengue (FHD), Síndrome do Choque do Dengue e Dengue com complicações. Diante do perfil epidemiológico para o município de Primavera do Leste, verifica-se a necessidade de investimento em ações de controle da doença, integrando todos segmentos da sociedade.

O conhecimento do perfil epidemiológico das intoxicações medicamentosas é um importante guia para a gestão de recursos destinados ao planejamento e à implementação de ações que previnam a ocorrência desse agravo. O presente trabalho buscou estudar o perfil das intoxicações medicamentosas ocorridas no município de Primavera do Leste-MT, entre 2007 a 2014. Foram avaliados dados secundários registrados no Sistema de Informação de Agravos de Notificação (SINAN), que permitiram a realização de um estudo epidemiológico descritivo e transversal em que se analisaram informações referentes ao perfil das vítimas (idade, sexo) e dos casos (circunstâncias, tipo de exposição e evolução dos casos). Registraram-se 52 casos, destes 73,1% (n=38) são vítimas do gênero feminino e 26,9% (n=14) do masculino. As intoxicações com medicamentos ocorreram em quase todas as faixas etárias (01 a 64 anos), porém a maioria das vítimas possuía entre 20 a 39 anos (n=26; 50%) e 15 a 19 (17,3%; n=9). As circunstâncias relacionadas às intoxicações foram: 73,1% (n=38) por tentativa de suicídio, 15,4% (n=8) por uso acidental e os demais pelo uso habitual, abuso, automedicação e violência/homicídio. Em 82,7% (n= 43) dos casos, as exposições foram agudas e únicas, em 9,6% (n=5) agudas repetidas, não sendo registrada exposição crônica. 84,6% (n= 44) das intoxicações evoluíram para cura sem sequelas. Registrou-se um óbito em função da tentativa de suicídio. As intoxicações por medicamentos são frequentes e representam um importante problema de saúde pública, que necessita de ações preventivas e educativas com foco nas vítimas e circunstâncias mais frequentes. Palavras-chave: Suicídio. Abuso de Medicamentos. Automedicação. AbstractKnowledge of the epidemiological profile of drug intoxications (Notification of Injury Information System) is an important guide for the resources management  intended to the planning and implementation of actions that prevent the occurrence of this outcome. The present study aimed to describe the drug intoxications profile occurring in the municipality of Primavera do Leste -MT, between 2007 and 2014. Secondary data recorded in  SINAN (Information System for Notifiable Diseases) were used to conduct a descriptive and cross - sectional epidemiological study in which information was analyzed regarding the victims’ profile (age, sex) and cases (circumstances, type of exposure and evolution of cases). There were 52 cases, of which 73.1% (n = 38) were females and 26.9% (n = 14) males. Drug intoxications occurred in almost all age groups (01 to 64 years), but the most of the  were between 20 and 39 years (n = 26; 50%) and 15 to 19 (17.3%; n = 9). The circumstances related to intoxication were: 73.1% (n = 38) for attempted suicide, 15.4% (n = 8) for accidental use and the others for habitual use, abuse, self-medication and violence / homicide. In 82.7% (n = 43) of the cases the exposures were acute and single, in 9.6% (n = 5) repeated acute, and chronic exposure was not recorded. 84.6% (n = 44) of intoxications evolved to cure without sequelae. A death was recorded due to suicide attempt. Drugs intoxications are frequent and represent a relevant public health problem that requires preventive and educational actions with a focus on the most frequent victims and circumstances. Keywords: Suicide. Drug Misuse.Self-Medication.