Objective: This clinical trial was conducted to compare the efficacy of fluoride varnish containing xylitol coated calcium and phosphate or potassium nitrate gel versus conventional fluoride varnish in the management of hypersensitivity of non-carious exposed root surfaces in adult patients. Material and Methods: 35 patients having 105 hypersensitive teeth were randomly allocated to be treated either using Embrace varnish (PULPDENT Corporation, Watertown, MA, USA) or UltraEz gel (Ultradent Products Inc. South Jordan, UT, USA) or Fluoride varnish FluoroDose (Centrix Inc., Milford, Connecticut, USA), all agents were used according to the manufacturers’ instructions. Hypersensitivity scores were assessed using the visual analogue scale (VAS), after applying different stimuli. The assessment was done at baseline, after 4 hours of application, after two days, then after 4, 8 and 12 months. Results: UltraEZ gel showed the best immediate relief with a significant difference from other treatment methods, fluoride varnish showed the best relief at both short and long term follow up periods. Embrace varnish showed the least success in reducing hypersensitivity. Conclusions: Fluoride varnish showed the best reduction in hypersensitivity values while UltraEZ showed the best immediate relief and Embrace varnish showed the least efficacy
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