Anaplastic carcinoma of the thyroid (ACT) is a rare subtype of thyroid neoplasm. This tumor represents approximately 5-10% of all thyroid malignancies and its poor prognosis has not changed in 25 years. ACT often arises in a long-standing thyroid nodule and has been documented to be associated with a variety of more well-differentiated thyroid carcinomas. We describe the cytologic features of a case in which the patient had a 10-yr history of a thyroid nodule. The ACT in this case had a cytologic and histologic appearance of several different subtypes of thyroid carcinomas.
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