Recent advances in biomaterials, thin film processing, and nanofabrication offer the opportunity to design electronics with novel and unique capabilities, including high mechanical stability and biodegradation, which are relevant in medical implants, environmental sensors, and wearable and disposable devices. Combining reliable electrical performance with high mechanical deformation and chemical degradation remains still challenging. This work reports temperature sensors whose material composition enables full biodegradation while the layout and ultrathin format ensure a response time of 10 ms and stable operation demonstrated by a resistance variation of less than 0.7% when the devices are crumpled, folded, and stretched up to 10%. Magnesium microstructures are encapsulated by a compostable‐certified flexible polymer which exhibits small swelling rate and a Young's modulus of about 500 MPa which approximates that of muscles and cartilage. The extension of the design from a single sensor to an array and its integration onto a fluidic device, made of the same polymer, provides routes for a smart biodegradable system for flow mapping. Proper packaging of the sensors tunes the dissolution dynamics to a few days in water while the connection to a Bluetooth module demonstrates wireless operation with 200 mK resolution prospecting application in food tracking and in medical postsurgery monitoring.

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Medical devices measure vital parameters such as pulse, respiration rate, and blood oxygenation, over periods of days or weeks in a continuous manner. Traditional systems only support such requirements in stationary applications where a constant power supply is available. Trends toward remote healthcare and telemedicine require wearable devices, able to provide similar functionalities in wireless mode. Miniaturized and thin form factors, desirable in wearable applications, set stringent constraints on the available power, and consequently on the accuracy and lifetime. Energy harvesting combined with low-power design and energy efficient processing can significantly extend the lifetime of wearable devices. This paper presents a wearable pulse oximeter assembled in a 3D ring-like geometry that achieves self-sustainability by exploiting efficient power management, solar energy harvesting, and ultra-low power processing in a multi-core microcontroller. The design strategy of combining onboard processing to monitor blood oxygenation and the transmission of only relevant information via a Bluetooth low-energy (BLE) interface, significantly reduces the overall energy consumption. Experimental results on the designed and developed prototype demonstrate that measuring the blood oxygenation once every minute with a sampling rate of 100 samples/s achieve accurate results at the daily energy consumption of 28 J including hourly BLE transmissions. The low-power design allows the system to be self-sustainable with just 64 min of sunlight per day or 12 hrs. of indoor home light. INDEX TERMS Wearable devices, energy harvesting, smart sensing, low power design, energy efficiency, self-sustaining.

Using profiles of phylogenetic profiles (P-cubic) we compared the evolutionary dynamics of different kinds of functional associations. Ordered from most to least evolutionarily stable, these associations were genes in the same operons, genes whose products participate in the same biochemical pathway, genes coding for physically interacting proteins and genes in the same regulons. Regulons showed the most plastic functional interactions with evolutionary stabilities barely better than those of unrelated genes. Further regulon analyses showed that global regulators contain less evolutionarily stable associations than local regulators. Genes co-repressed by global regulators had a higher evolutionary conservation than genes co-activated by global regulators. However, the reverse was true for genes co-repressed and co-activated by local regulators. Of all the regulon-related associations, the relationship between regulators and their target genes showed the most evolutionary stability. Different negative data sets built to contrast against each of the analysed kinds of modules also differed in evolutionary conservation revealing further underlying genome organization. Applying P-cubic analyses to other genomes might help visualize genome organization, understand the evolutionary importance and plasticity of functional associations and compare the quality of data sets expected to reflect functional interactions, such as those coming from high-throughput experiments.