The increasing availability of appliances for measuring lung function in infants may allow clinical and epidemiological applications. The aim of the present study was to establish reference values for tidal breathing lung function in awake newborn infants and to investigate potential sources of variability. Tidal flow-volume loops were measured in 803 awake, healthy infants (427 males and 376 females) and passive respiratory mechanics (single-breath occlusion technique) in 664. Mean postnatal age was 2.7 +/- 0.9 (sd) days, gestational age 39.8 +/- 1.4 weeks and birthweight 3.59 +/- 0.49 kg. Tidal expiratory volume (Vt), peak tidal expiratory flow (PEF), and mid-expiratory flow increased significantly with increasing birthweight. Flow ratios: ratio of time to PEF to total expiratory time (Tpef/Te), ratio of volume to PEF to total expiratory volume (Vpef/Ve); and ratio of tidal flow at 25% remaining expiration to PEF (TEF25/PEF), were highest in 1 day old infants (medians 0.39, 0.46 and 0.81 respectively), decreasing to a minimum in 4-5 day old infants, but were not influenced by birthweight. Tidal flows and flow ratios were higher in males versus females, even after weight adjustment. Respiratory rates correlated significantly with tidal flows (r = 0.66), inversely with Vt (r = 0.40), but not with flow ratios. Mean compliance of the respiratory system was 1.18 ml.cmH2O-1.kg birthweight (95% confidence interval (95% CI) 1.15-1.21) and mean resistance 0.051 cmH2O.ml-1.s (95% CI 0.049-0.054). These results demonstrate that lung function in awake healthy infants varies according to weight, gender and postnatal age.(ABSTRACT TRUNCATED AT 250 WORDS)
A Al lu um mi in ni iu um m p po ot tr ro oo om m a as st th hm ma a: : t th he e N No or rw we eg gi ia an n e ex xp pe er ri ie en nc ce e J. Kongerud* + , J. Boe*, V. Søyseth**, A. Naalsund*, P. Magnus + Aluminium potroom asthma: the Norwegian experience. J. Kongerud, J. Boe, V. Søyseth, A. Naalsund, P. Magnus. ERS Journals Ltd 1994. ABSTRACT: Work-related asthma in aluminium potroom workers, is reviewed and discussed, mainly on the basis of own investigations. The occurrence of work-related asthma has been shown to be associated with the duration of potroom employment, although the prevalence of asthmatic symptoms is not significantly different from that of the general population. Typical manifestations of occupational asthma are described in potroom workers, and a close relationship between the levels of fluoride exposure and work-related asthmatic symptoms has been observed. The existence of occupational asthma in aluminium potroom workers has been confirmed by characteristic patterns of repeated peak flow measurements, supported by changes in methacholine responsiveness in workers with suspected work-related asthma. However, no immunological test is available to establish the diagnosis. Methacholine challenge appears to be inappropriate for screening aluminium potroom workers in order to detect work-related asthma. Current smoking, but not self-reported allergy, is a risk factor for potroom asthma. A family history of asthma and previous occupational exposure may have some effect on the risk of developing symptoms.The prognosis of potroom asthma seems to depend on early replacement to unexposed work. The pathogenetic mechanisms are unknown, although some studies indirectly imply a hypersensitivity reaction.Future studies involving specific bronchial challenge appear to be necessary to find the causal agent(s) of aluminium potroom asthma.
In a national cross-sectional study, the prevalence of neck/shoulder and low-back disorders and their relationship to work tasks and perceived psychosocial job stress was studied among forestry employees. The data were collected by occupational health service staff using Karasek's demand/control questionnaire for the psychosocial measures and the Standardized Nordic questionnaire for the analysis of musculoskeletal disorders. Based on data about past and present work tasks, the study population was classified into three groups: 645 manual workers, 66 machine operators and 124 administrative workers. Low-back disorders were more common among the manual workers than among the administrative workers [odds ratio (OR) = 1.98]. For the machine operators and manual workers, an increasing level of psychological demands was significantly associated with an increased prevalence of low-back disorders. The prevalence of neck/shoulder disorders was significantly higher among the machine operators (OR = 3.37) and manual workers (OR = 2.34) than among the administrative workers. An increasing level of psychological demands combined with a decreasing level of intellectual discretion was associated with an increased prevalence of neck/shoulder disorders. Authority over decisions was not associated with musculoskeletal disorders. In conclusion, musculoskeletal disorders were associated with both physical and psychosocial work factors. The modest strength of the associations between each individual independent variable and the outcome measure shows, however, that a substantial reduction in the prevalence of musculoskeletal disorders may be difficult to achieve. Nevertheless, the study clearly suggests that in the forestry industry attention should be paid to psychosocial work factors in future organizational changes and preventive programmes.
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