A rhodium-catalyzed C−H amidation/cyclization
sequence provides benzothiadiazine-1-oxides from sulfoximines and
1,4,2-dioxazol-5-ones in good yields. The reaction is characterized
by a high functional group tolerance and, in contrast to most previous
transformations of this type, is well-suited for S-alkyl-S-aryl-substituted sulfoximines.
By visible-light photoredox catalysis with copper complexes, sulfoximidoyl chlorides add to terminal aryl alkynes to give the corresponding (E)-β-chlorovinyl sulfoximines with exclusive regio-and stereoselectivities in high yields. Two representative products have been characterized by X-ray crystal structure analysis. Radicals appear to be decisive intermediates. As demonstrated by two subsequent reactions, the products can be derivatized.
A novel CuBr-catalyzed hydroxytrifluoromethylation reaction was investigated. Substituted 3-benzylidene-2-arylisoindolin-1-ones were reacted with sodium trifluoromethanesulfinate to afford substituted-3-hydroxy-2-aryl-3-(2,2,2-trifluoro-1-arylethyl)isoindolin-1-one.
Visible light induces C–C-bond cleavage reactions of ketones, which can be utilized for N-acylations of sulfoximines. No (photo)catalyst is required, and the reactions occur at ambient temperature in air. The...
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