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This study suggests that infliximab may have a neuroprotective effect through its anti-apoptotic property on hydrocephalus induced optic pathways injury.

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Embryologic studies revealed that it is common to encounter different histological subtypes of FT pathology. However, the presence of peripheral nerve cells in the FT is important for neurosurgical practice due to the risk of sectioning a functional structure during surgery. In our analysis, we demonstrated the high frequency of PNF in FT pathology. However, since none of the patients showed any symptoms of neurologic deterioration, we considered that these fibers were probably not functional. Our findings emphasize the importance of neuromonitoring in TCS surgery. Although we consider that most of the fibers are probably not functional, neuromonitoring after surgery may prevent serious complications.

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BACKGROUND:The aim of this study was to investigate clinical manifestation, diagnosis, treatment, and prognosis of patients with primary gastrointestinal non-Hodgkin lymphoma (PGI NHL), whose initial presentation was bowel obstruction or perforation.

AIM: To evaluate the frequency and prognostic significance of microsatellite instability (MSI) in patients with glioblastoma (GBM), an immunohistochemical analysis of mismatch repair (MMR) proteins was performed. MATERIAL and METHODS: A total of 71 patients with GBM who underwent surgery between 2011 and 2019, were included in the study. MMR protein expression was examined using immunohistochemistical analysis of tumor tissue samples; the association between the MMR status and clinicopathological findings was evaluated. RESULTS: Immunohistochemical analysis revealed expressions of MLH1, MSH2, MSH6, and PMS2 proteins in 67 (94.4%), 65 (91.5%), 67 (94.4%), and 64 (90.1%) patients, respectively. Among the 71 patients, 64 (90.1%) expressing all MMR proteins were considered microsatellite stable (MSS), and 7 (9.9%) patients showing loss of at least one of the MMR proteins were considered to show MSI. Tumor recurrence was noted in 25 (39.1%) patients in the MSS GBM group, and 4 (57.1%) patients in the MSI GBM group (p=0.433). The overall median survival was 30.65 ± 5.1 and 10.71 ± 5.2 months in the MSS GBM and MSI GBM groups, respectively (p=0.059). CONCLUSION: The results of this study showed no significant relationships between MMR protein expression and recurrence rates or overall survival in patients with GBM.

AIm:To investigate the effects of hyperbaric oxygen treatment on epidural fibrosis formation in an experimental laminectomy model. mAteRIAl and methods: Twenty-four Wistar rats underwent L5-L6 total laminectomy and divided into three groups. Animals in the control group received no further treatment while animals in short and long term groups received 2,5 ATM ABS of hyperbaric oxygen for 3 and 7 days, respectively. The amount of epidural fibrosis was analyzed histologically at the end of 42 days of follow up. Results:The ratio of severe fibrosis was 57% in the control, 29% in the short HBOT, and 14% in the long HBOT groups. Although there was a clear trend towards having less fibrosis in the HBOT groups, the difference did not reach to the level of statistical significance (p=0.242), probably due to small number of animals used in this preliminary study. ConClusIon:Our findings suggest that hyperbaric oxygen treatment may have favorable effects on epidural fibrosis. Further studies with larger cohorts are required to prove our results KeywoRds:Epidural fibrosis, Failed back syndrome, Hyperbaric oxygen, Laminectomy, Peridural fibrosis ÖZ AmAÇ: Bu çalışmada, deneysel laminektomi modeli kullanılarak ratlarda oluşturulan epidural fibrosis ve buna bağlı olarak gözlenen ağrı cevabı üzerine hiperbarik oksijen tedavisinin etkilerinin incelenmesi amaçlanmıştır. yÖntem ve GeReÇleR: Yirmi dört wistar cinsi rata L5 L6 seviyelerinden total laminektomi yapılıp ratlar rastgele bir şekilde 3 gruba ayrılmıştır. Kontrol grubundaki hayvanlar her hangi bir ek tedavi almazken kısa ve uzun süreli tedavi gruplarındaki hayvanlara sırası ile 3 ve 7 gün boyunca 2.5 ATM ABS hiperbarik oksijen tedavisi uygulanmıştır. Kırkiki günlük takip süresi sonunda laminektomi sahasındaki epidural fibrosis miktarı histolojik olarak değerlendirmiştir.BulGulAR: Grade 3 fibrozis kontrol grubunda %57 oranında gözlenirken kısa HBOT grubunda %29; uzun HBOT grubunda ise %14 oranında gözlenmiştir. Her ne kadar HBOT alan gruplarda daha az fibrozis gözlenmiş olsa da gruplar arasındaki farklar istatistiksel olarak anlamlı bulunmamıştır (p=0.242). Bunun nedeninin, bu öncü çalışmada kullanılan hayvan sayısının azlığı olarak düşünülmüştür. sonuÇ: Çalışma bulguları hiperbarik oksijen tedavisinin epidural fibrozis üzerine olumlu etkileri olabileceğini göstermektedir. Daha çok deneğin katıldığı farklı dizaynda çalışmalara ihtiyaç duyulmaktadır.