Primary small intestinal non-Hodgkin lymphomas that have been diagnosed after emergency surgery

Avci, Tevfik; Yabanoğlu, Hakan; Arer, İlker Murat; Koçer, Nazım Emrah; Çalışkan, Kenan; Börcek, Pelin; Ekici, Yahya

doi:10.5505/tjtes.2016.02359

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…Emergency surgery was performed for 36.8% (n = 7) of the patients in the present study. One published study from Turkey reported that the 5-year survival rate was 64.3% in 17 primary small intestinal non-Hodgkin's lymphoma patients (12 patients DLBL) after emergency surgery [23]. In the present study, the prognosis of all cases with emergency surgery was good.…”

Section: Discussionsupporting

confidence: 57%

Clinical outcomes of surgical management for primary gastrointestinal diffuse large B-cell lymphoma: At a single institution experience

Jang

Lim

Kuk

et al. 2017

Korean J Clin Oncol

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The study aimed to analyze peri/postoperative outcomes and long-term oncologic outcomes after surgical management for primary gastrointestinal diffuse large B-cell lymphoma (DLBL). Methods: Between January 2001 and December 2013, 19 patients who underwent surgery for primary gastrointestinal DLBL were retrieved from a retrospective database. Results: With a median follow up of 49.2 months, the most common tumor locations were the terminal ileum and cecum (n=14, 73.7%) and stomach (n=4, 21.1%). The most common clinical symptoms were abdominal pain (n=15, 78.9%) and intussusceptions (n=5, 26.3%). None of the patients had B symptoms. Emergency surgery was undertaken in 36.8% (n=7) of the patients. Mean mass size was 8.4 cm; 4 patients (21.1%) had a bulky mass (>10 cm). The International Prognostic Index (IPI) scores were low (n=11, 57.9%), low-intermittent (n=7, 36.8%), and high-intermittent (n=1, 5.3%). Patients` staging was IE (n=9, 47.4%), IIE (n=8, 42.1%), and IVE (n=2, 10.5%) based on the Ann Arbor staging system, and I (n=2, 10.5%), II1 (n=5, 26.4%), IIE (n=10, 52.6%), and IV (n=2, 10.5%) based on the Lugano staging system. B-lymphocyte antigen CD20 was positive in most patients (n=17, 89.5%) and Ki-67 was high (>70%) in 12 patients (63.2%). Two types of chemotherapy were administered: cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (n=5, 26.3%), rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (n=13, 68.4%). The 5-year disease-free survival rate was 94.4% and the 5-year overall survival rate was 89.5%. Conclusion: Surgery for primary gastrointestinal DLBL is feasible and acceptable. Low staging of primary gastrointestinal DLBL has good prognosis.

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Section: Discussionsupporting

confidence: 57%

Clinical outcomes of surgical management for primary gastrointestinal diffuse large B-cell lymphoma: At a single institution experience

Jang

Lim

Kuk

et al. 2017

Korean J Clin Oncol

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“…The pathogenesis of GI lymphomas remains unknown. Nonetheless, a number of risk factors have been implicated such as immunodeficiency syndromes, HIV, inflammatory bowel disease and post-transplant [5,7]. Half of the cases of GI lymphomas involve the stomach, and one-third of cases involve the small bowel [4].…”

Section: Discussionmentioning

confidence: 99%

“…A wide range of nonspecific clinical symptoms has been reported with intestinal lymphomas. Abdominal pain is the main presenting symptom, and B symptoms are not commonly seen [7]. Bowel obstruction is a common disease manifestation, reported in almost 40% of patients with intestinal NHL in one series [5].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, a wide range of nonspecific symptoms can be associated with small bowel lymphoma, with abdominal pain being the most common [5]. While bowel obstruction is a possible manifestation of the disease, a review of the literature favors the jejunum or the ileum as sites of the obstruction rather than the duodenum [6-7]. Furthermore, peritoneal involvement by lymphoma, known as peritoneal lymphomatosis, is less common in small bowel lymphoma [8-9].…”

Section: Introductionmentioning

confidence: 99%

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Obstructing Duodenal Diffuse Large B-cell Lymphoma with Peritoneal Lymphomatosis with Exceptional Response to R-CHOP

Zaarour

Busack

Munker

2019

Cureus

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Primary small bowel tumors are uncommon and usually carry a poor prognosis. Adenocarcinoma is the predominant histological type while lymphoma is far less common. Small bowel diffuse large B-cell lymphoma (DLBCL) can mimic adenocarcinoma; thus, the distinction can be challenging before tissue examination is performed. Bowel obstruction, as well as peritoneal involvement, are often seen in gastrointestinal (GI) adenocarcinoma cases; however, these features are extremely uncommon with GI lymphomas. Herein, the authors report an unusual case of an obstructing duodenal mass with peritoneal involvement, which was highly suspicious for an advanced duodenal adenocarcinoma. Surprisingly, sampling of the tumor revealed a diffuse large B-cell lymphoma.

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“…The small bowel [ 2 ] is the second leading site, after the stomach [ 3 ], for primary gastrointestinal non-Hodgkin’s lymphoma (PGI NHL). It commonly causes abdominal pain, changes in bowel habits, weight loss, a palpable abdominal mass and blood in the stool [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Small bowel lymphoma presenting as inguinal hernia: case report and literature review

et al. 2018

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BackgroundInguinal hernia is one of the most common benign pathologies that primarily affects men. Primary gastrointestinal non-Hodgkin’s lymphoma (PGI NHL) is the most common type of extranodal lymphoma. This study reports a rare case in which these two conditions co-exist.Case presentationAn 85-year-old male complained of bowel movement pattern change, abdominal distension and loss of weight, without vomiting but with nausea. A computed tomographic scan of the abdomen showed a small bowel obstruction caused by a migration of a small bowel loop in the right inguinal canal, with a clinically non-reducible inguinal hernia. The patient underwent surgery. The histopathological report showed small bowel large B cell non-Hodgkin’s lymphoma.ConclusionWhen the diagnosis of the contents of an inguinal hernia is not well-established, surgery should be performed as soon as possible to ensure the cure of the disease and the correct diagnosis of the contents.

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Primary small intestinal non-Hodgkin lymphomas that have been diagnosed after emergency surgery

Abstract: BACKGROUND:The aim of this study was to investigate clinical manifestation, diagnosis, treatment, and prognosis of patients with primary gastrointestinal non-Hodgkin lymphoma (PGI NHL), whose initial presentation was bowel obstruction or perforation.

Cited by 4 publications

References 17 publications

Clinical outcomes of surgical management for primary gastrointestinal diffuse large B-cell lymphoma: At a single institution experience

Clinical outcomes of surgical management for primary gastrointestinal diffuse large B-cell lymphoma: At a single institution experience

Obstructing Duodenal Diffuse Large B-cell Lymphoma with Peritoneal Lymphomatosis with Exceptional Response to R-CHOP

Small bowel lymphoma presenting as inguinal hernia: case report and literature review

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