A practical silver‐catalyzed decarboxylative allylation of α,α‐difluoroarylacetic acids with allyl sulfones is described, which provides a variety of β,β‐difluorinated alkenes in good yields. Notably, the reaction proceeds smoothly in water with good functional group tolerance. The practicality and synthetic value of this process was demonstrated by scaled‐up experiment and elaboration of the products via reduction or Heck reaction. Primary mechanism investigations suggest that a radical process might be involved.
An
efficient and practical protocol for visible-light-induced decarboxylative
cyclization of 2-alkenylarylisocyanides with α-oxocarboxylic
acids has been developed, which afforded a broad range of 2-acylindoles
in moderate to good yields. The reaction proceeds through a cascade
of acyl radical addition/cyclization reactions under irradiation of
an Ir3+ photoredox catalyst without external oxidants and
features simple operation, scalability, a broad substrate scope, and
good functional group tolerance.
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