Silver‐Catalyzed Decarboxylative Allylation of Difluoroarylacetic Acids with Allyl Sulfones in Water

Abstract

A practical silver‐catalyzed decarboxylative allylation of α,α‐difluoroarylacetic acids with allyl sulfones is described, which provides a variety of β,β‐difluorinated alkenes in good yields. Notably, the reaction proceeds smoothly in water with good functional group tolerance. The practicality and synthetic value of this process was demonstrated by scaled‐up experiment and elaboration of the products via reduction or Heck reaction. Primary mechanism investigations suggest that a radical process might be involved.

Monitoring Biomaterials with Light: Review of Surface Plasmon Resonance Biosensing Using two Dimensional Materials

“…LPFGs are usually produced by using electric arc discharge or amplitude masks. Additionally SPR generation can be achieved from optimization of grating structures surrounded by using a thin metal film mostly gold or silver [48]. Thickness of film metal was between 30 nm and 70 nm.…”

Promising reagents for difluoroalkylation

“…In 2020, the Yao group found that the decarboxylative allylation of α,α-difluoroarylacetic acids with allyl sulfones can also be catalyzed by silver in water. 130 Preliminary mechanistic investigations suggest that a radical process and β-elimination might be involved. The photoinduced decarboxylative difunctionalization of maleic anhydride with amine and fluorinated alkyl iodides was reported by the Zhang group (Scheme 58).…”

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