A fibropapilomatose (FP) é uma doença multifatorial, neoplásica e infecciosa que afeta todas as espécies de tartarugas marinhas, e o Chelonid alphaherpesvirus 5(ChHV5) tem sido apontado como o agente etiológico primário. Essa doença é caracterizada por tumores cutâneos, mas fibromas viscerais, mixofibromas e fibrossarcomas também têm sido relatados e podem interferir nas funções sistêmicas. Apesar de descrições anteriores de neoplasias viscerais em tartarugas marinhas do Havaí e Flórida, algumas infectadas pelo ChHV5, há poucos relatos de tumores não cutâneos em tartarugas marinhas no Brasil. Para preencher essa lacuna, analisamos amostras de neoplasias internas de quatro tartarugas verdes (Chelonia mydas) através de técnicas histopatológicas e moleculares. Neoplasias cutâneas foram quantificadas e classificadas de acordo com seus tamanhos e escores para determinar a severidade da FP, e a presença de tumores internos foi confirmada postmortem durante necropsia. Quarenta e oito tumores cutâneos (7-23 por indivíduo) foram encontrados nas tartarugas verdes amostradas, e a severidade da FP foi classificada como leve (2 indivíduos) e moderada (2 indivíduos). Neoplasias viscerais foram encontradas em pulmão (n=4), coração (n=1), intestino (n=2), esôfago (n=1), estômago (n=1), fígado (n=1), baço (n=1), músculo esquelético (n=1) e rim (n=2), sendo classificadas como fibromas e uma como mixofibroma renal. Não detectamos DNA do ChHV5 nos fibromas esofágico, muscular esquelético e hepático. Nossa pesquisa relata nova descrição de mixofibroma renal e detecção do ChHV5 em neoplasias viscerais de tartarugas verdes no Brasil, melhorando o conhecimento sobre prevalência, localização anatômica e severidade dos tumores internos associados à FP.
The aim of this work was to trace an epidemiological and clinical profile of oral squamous cell carcinoma (SCC) cases diagnosed as lip and tongue SCC from June 2001 to 2018 at a pathology anatomy service located in Northeastern Brazil. Age, sex, duration, location, growth type, staining, metastasis, etiologic agents and lesion size data were obtained from patient clinical files and histopathological reports. A total of 124 cases were recorded, with tongue SCC being the most prevalent. The common characteristics of both assessed SCCs included higher frequency in men, mean age of 60 years old, evidence mostly of exophytic lesions and maximum size of 4 cm, predominantly diagnosed after a maximum of 1 year of appearance. Regarding divergent findings, lip SCC occurred mostly in the lower portion of the lip, presenting a predominantly leukoplastic color, with regular smoking habits and sunlight identified as the main etiological agents, and no strong relation to metastasis. On the other hand, tongue SCC mostly exhibiting predominantly erythroleukoplastic staining, with a greater relationship to alcoholassociated smoking and regular smoking habits. The highest percentage of patients with metastasis presented tongue SCC. Although lip and tongue SCC display a male preference, an increasing amount of female involvement has been noted over the years, due to the adoption of deleterious habits such as smoking and alcoholism. Tongue SCC presented a greater relationship with metastasis and clinical leukoeritroplastic evidence. This greater aggressiveness could be related to the unfavorable location of these lesions in relation to lip SCC, sometimes making it difficult to identify in their early development stages.
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