Agents that inhibit steroidogenesis are useful in all forms of Cushing's syndrome and are effective in about 70% of patients. Main indications for drug therapy include preparation for surgery, persistence or recurrence after surgery, while awaiting for the effect of radiation therapy, occult ectopic ACTH syndrome, severe hypercortisolism and malignancy related hypercortisolism.
Endogenous and exogenous pathways determine plasma levels of cholesterol and lipoproteins. Plasma cholesterol levels and coronary heart disease risk can be reduced pharmacologically by decreasing cholesterol synthesis, increasing its elimination and/or reducing its absorption from the intestine. The more profound knowledge about cholesterol homeostasis has allowed the development of several lipid-lowering drugs with different mechanisms of action, with the purpose of reducing both morbidity and mortality associated with coronary heart disease. Two new and more potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), also called superstatins (rosuvastatin and pitavastatin), are being studied for their ability to improve lipid profiles. Rosuvastatin is a potent, hepato-selective and relatively hydrophilic statin with a low propensity for muscle toxicity and drug interactions. Pitavastatin is another statin with a high oral bioavailability and minimal propensity for cytochrome p450-mediated drug interactions. Rosuvastatin seems to be more potent than other available statins while pitavastatin presents with a similar potency to that of atorvastatin. Another promising approach for lowering total and low-density lipoprotein cholesterol levels is inhibition of cholesterol absorption. A wide variety of new agents with the capacity for inhibiting the intestinal cholesterol absorption is currently being investigated. Ezetimibe is a selective cholesterol absorption inhibitor whose clinical efficacy has been recently demonstrated both in monotherapy and in combination with other lipid-lowering drugs. Colesevelam, a new bile acid sequestrant, has shown a clinical efficacy similar to that of other resins, with minimal gastrointestinal side effects, improving tolerability and patient compliance. Other lipid-lowering drugs with the ability to act at the enterocyte level, such as avasimibe and implitapide, are currently being investigated in humans.
Although there is literature on the willingness to share visual data in the frame of web surveys and the actual participation when asked to do so, no research has investigated the skills of the participants to create and share visual data and the availability of such data, along with the willingness to share them. Furthermore, information on the burden associated with answering conventional questions and performing visual data-related tasks is also scarce. Our paper aims to fill those gaps, considering images and videos, smartphones and PCs, and visual data created before and during the survey. Results from a survey conducted among internet users in Spain (N = 857) show that most respondents know how to perform the studied tasks on their smartphone, while a lower proportion knows how to do them on their PC. Also, respondents mainly store images of landscapes and activities on their smartphone, and their availability to create visual data during the survey is high when answering from home. Furthermore, more than half of the participants are willing to share visual data. When analyzing the three dimensions together, the highest expected participation is observed for visual data created during the survey with the smartphone, which also results in a lower perception of burden. Moreover, older and lower educated respondents are less likely to capture and share visual data. Overall, asking for visual data seems feasible especially when collected during the survey with the smartphone. However, researchers should reflect on whether the expected benefits outweigh the expected drawbacks on a case-by-case basis.
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