Considerable interest is being taken at present in a syndrome characterized by precocious puberty, pigmentation of the skin and an unusual type of generalized fibrocystic disease of the skeleton. In a recent article McCune and Bruch 1 presented a detailed description of this entity, which they termed osteodystrophia fibrosa. In their r\l=e'\sum\l=e'\of the literature2 they stated that 14 cases of the condition had been reported to date. The presentation of our 2 cases contributes nothing new to the etiology of the condition, but the cases are of interest as abnormal values for cholesterol, blood fat and blood sugar were found. REPORT OF CASESCase 1.\p=m-\J.P., a girl, was first admitted to the Hospital for Sick Children on July 4, 1934. At this time she was 10 years of age. The mother of the patient was 34 years of age at the birth of the child and the father 44 years. Both parents were healthy. One brother and two sisters were alive and well. The patient had had no other illness except scarlet fever at the age of 7 years and chickenpox at From the
In 1932, one of us (Summerfeldt1) reported that when a group of normal children were fed for ten weeks a special cereal mixture rich in vitamin B and various mineral elements in place of the commonly used cereals a marked increase in weight resulted. It was suggested that this increased gain in weight was due to the high vitamin B content of the cereal. In order to obtain further information as to the factor present in this cereal which brought about the increased gain in weight, and also to determine whether the increased gain in weight would be continued for a period longer than ten weeks, the present investigation was undertaken. INVESTIGATIONChildren in a large orphanage were divided into three groups of from twenty to twenty-three children each, the groups containing about equal numbers of girls and boys of similar ages. The ages of the children on the nearest birthday varied from 5 to 14 years. They had been in the institution for at least two months before the period of observation began, so that they had become accustomed to the institu¬ tional regimen. All the children were of British descent. The weight and height at the beginning of the period of observation did not deviate by more than 10 per cent from the normal values for the ages given in the tables of the Toronto Health Department.The diet of the institution was good. The average daily consumption of milk per child was 24 ounces (709.77 cc). Each child consumed from one to four eggs weekly, depending on the season. Meat was served from three to six times weekly. One or two vegetables were usually served daily in addition to potatoes. Fresh fruit, usually in the form of an apple or occasionally of an orange or pear, was served daily for approximately nine months. During the spring and early summer months dried or preserved fruits were frequently given.The first, or control, group was kept on the regular diet of the institution. These children received 3 ounces (85 Gm.), by dry weight, of oatmeal or cracked wheat for breakfast each morning.
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