Osteodystrophia Fibrosa

Abstract

Considerable interest is being taken at present in a syndrome characterized by precocious puberty, pigmentation of the skin and an unusual type of generalized fibrocystic disease of the skeleton. In a recent article McCune and Bruch 1 presented a detailed description of this entity, which they termed osteodystrophia fibrosa. In their r\l=e'\sum\l=e'\of the literature2 they stated that 14 cases of the condition had been reported to date. The presentation of our 2 cases contributes nothing new to the etiology of the condition, but the cases are of interest as abnormal values for cholesterol, blood fat and blood sugar were found. REPORT OF CASESCase 1.\p=m-\J.P., a girl, was first admitted to the Hospital for Sick Children on July 4, 1934. At this time she was 10 years of age. The mother of the patient was 34 years of age at the birth of the child and the father 44 years. Both parents were healthy. One brother and two sisters were alive and well. The patient had had no other illness except scarlet fever at the age of 7 years and chickenpox at From the

Polyostotic Fibrous Dysplasia

“…Four examples have been reported following neonatal jaundice (McCune and Bruch, 1937;Summerfeldt and Brown, 1939;Braid, 1939, two cases). Braid suggested that the condition might result from early liver damage, but there has been no more evidence to support this.…”

“…al., (1946) and the single cases with neurological lesions of Albright, Scoville and Sulkowitch (1938) and of Dockerty, et al (1945) have not been included because of the possibility of non-congenital causation. Summerfeldt and Brown's (1939) case with an I.Q. of 70 must be included in tie lower normal range.…”

A case of Albright's syndrome (osteitis fibrosa disseminata)

“…severe degree of bilateral knock-knee, the left worse than on the other hand, it probable that the the right. Hyperthyroidism has been observed in some cases (Albright et al, 1938;Summerfeldt and Brown, 1939), and in one case recorded by McCune and Bruch (1937), and later by Sternberg and Joseph (1942), there was a history of thyrotoxicosis, and the autopsy findings included, in addition to hyperplasia of the thyroid gland, the thymus, and lymphoid tissue generally, basophilic adenoma of the pituitary, narrowing of the cortex and hypertrophy of the medulla of the adrenals, patent foramen ovale, and a Meckel's diverticulum. Multiple arteriovenous aneurysms involving the left upper extremity and probably the left lower extremity (StaufFer et al, 1941) ; co-arctation of the aorta and a rudimentary left kidney (Lichtenstein and Jaffe, 1942); and probable congenital cardiac defect (Dockerty et al, 1945) have been observed in single cases.…”