The representation of the visual field in the architectonically defined transition zone between areas 17 and 18 of cat cerebral cortex was assessed by recording the activities and plotting the receptive fields of neurons at 2327 sites along 148 electrode penetrations made in 19 cats. The results show that the transition zone contains a significant representation of the ipsilateral visual hemifield although not all elevations in the visual field are represented to the same extent. The shape of the field region represented resembles an hour glass, for the region represented is narrowest on the 0-deg horizontal meridian and increasingly wider at progressively more positive and negative elevations. When receptive-field centers are considered, the extent of the representation reaches to -2.5 deg on the 0-deg horizontal meridian and to 10 or more degrees towards the field periphery. When receptive-field areas are considered, the representation at the 0-deg horizontal meridian extends to -3.6 deg and to beyond 20 deg at other elevations. In contrast, the visual-field representations in flanking areas 17 and 18 are essentially limited to the contralateral hemifield. The presence of a distinct representation of part of the ipsilateral hemifield in the transition zone suggests that the zone may have connections distinctly different from those of the adjacent areas. The observations bear on the problems of understanding the visual pathways in hypopigmented cats and binocular disparity mechanisms about the midline.

Reversible inactivation by cooling of the transcallosal projecting neurons in areas 17 and 18 of one hemisphere bring about complex changes in the spontaneous and evoked activity of neurons in the callosal receiving zone of the opposite hemisphere. These changes include increase and decreases in evoked and spotaneous activities. Overall, 90% of neurons in alyers II and III, 50% in layer IV, and 100% in layers V and VI were affected by the block of transcallosal input. The complexity of the changes was greatest in layers II and III, which are the major callosal recipient layers. The results indicate that many excitatory and inhibitory circuits are under the direct control of transcallosal fibers in the normally fuctioning brain.

The purpose of this perspective is twofold: 1) to alert and inform the neurospychology and neurology communities on how animal models can improve our understanding of spatial neglect in humans, and 2) to serve as a guide to rehabilitation strategies. Spatial neglect is a neurological syndrome that is inextricably linked to the ability to overtly or covertly reorient attention to new loci. Literature describing variants of neglect leads to the perception of lesion-induced neglect as a uniquely human syndrome for which there are limited treatment options. To the contrary, neglect has been reversed in laboratory animals, and results show that adequate neural representations and motor mechanisms for reversal are present despite damaged or deactivated cerebral cortex. These results and conclusions provoke thought on strategies that can be employed on humans to cancel neglect, and they suggest that long-term amelioration of neglect can be induced by training of specific bypass circuits.