(1) Background: This study was planned to assess the concentration of antihypertensive drugs (AHD) in the blood serum in patients with controlled and uncontrolled arterial hypertension (AH). (2) Methods: We assessed 46 patients with AH. Based on the results of 24 h blood pressure monitoring (ABPM), the patients were randomized into two groups. The first group consisted of the patients with controlled AH; the second group consisted of the patients with uncontrolled AH. Venous blood was taken in both groups of patients in the morning before and 2 h after taking drugs to assess the concentration of lisinopril, amlodipine, valsartan, and indapamide. (3) Results. The first group included 27 patients, and the second group 19 patients. In patients with uncontrolled AH, the median concentrations of lisinopril, indapamide, amlodipine, and valsartan before and after taking the drugs did not differ from patients who reached the target BP values. (p > 0.05). In some patients with uncontrolled and controlled (shown for the first time) AH the concentration of AHD was below the limit of quantitative determination. (4) Conclusions. The obtained results indicate that the pharmacokinetics of AHD, apparently, does not play a significant role in the development of ineffectiveness of the ongoing therapy for AH. Therapeutic drug monitoring can be used to test adherence to the treatment.
First implementation of a new well integrity management solution with integrated and automated workflows, the Well Integrity Management solution (WIMS) that helps company to minimize risks and production loss by the real-time monitoring of the operating limits of sour gas wells. Leveraging digital twin technology, the new software enables engineers to rapidly identify high-risk wells, take corrective actions faster, and mitigate issues to maximize well availability. Previously, the process of monitoring well integrity was based on the multiple software applications which is time-consuming. To address the challenge, we developed a WIMS coupled with the well engineering analysis approach. The system achieves the following: Representative and accurate well barrier equipment inventory for the entire asset.Safely operate critical HPHT wells to their maximum potential,Eliminate critical and costly barrier failures while minimizing production interruption through automated workflows and alert triggers,Free SMEs to perform critical well integrity management tasks, including technical reviews of sensitivity analysis that determine more accurate MAASP/MAWOP values,Track corporate KPIs and report regulatory requirements effectively. WIMS integrates source system for the well engineering applications. A first-of-its kind, WIMS uses Real Time engineering analytics and artificial intelligence to run as a Digital Twin for well's Operating Limits and diagnoses potential failures. It also measures, reports and displays most realistic well integrity status for the wells, based on company well integrity standards, processes and best practices. This paper details how we were able to successfully address these challenges which encouraged us mutually to work towards further integration with engineering tools and more automation of WIMS processes. Important Note: All well data, engineering analysis, operating limits and well information etc., displayed or referred to in this publication, are not necessarily actual and only used for illustration purposes.
Abstract-The method of key sharing between a mobile unit and a base station through a wireless MIMO-based fading channel is investigated. The description of a key distribution protocol is given. The expression to estimate the correct key bit agreement based on the use of guard interval is proved. Statistical properties of the key string are tested using the NIST criteria. Impossibility of key string eavesdropping by illegal users is guaranteed due to small values of correlation between legal and eavesdropper carrier phases. Numerical examples show that the MIMO system with 8 antennas is able to agree 256 bits with a reliability value 0.99 for SNR equal to 35 dB. This experiment confirms that the MIMO scenario is especially effective for secret key distribution.
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