BackgroundAccording to some international studies, patients with acute coronary syndrome
(ACS) and increased left atrial volume index (LAVI) have worse long-term
prognosis. However, national Brazilian studies confirming this prediction are
still lacking.ObjectiveTo evaluate LAVI as a predictor of major cardiovascular events (MCE) in patients
with ACS during a 365-day follow-up.MethodsProspective cohort of 171 patients diagnosed with ACS whose LAVI was calculated
within 48 hours after hospital admission. According to LAVI, two groups were
categorized: normal LAVI (≤ 32 mL/m2) and increased LAVI (> 32
mL/m2). Both groups were compared regarding clinical and
echocardiographic characteristics, in- and out-of-hospital outcomes, and
occurrence of ECM in up to 365 days.ResultsIncreased LAVI was observed in 78 patients (45%), and was associated with older
age, higher body mass index, hypertension, history of myocardial infarction and
previous angioplasty, and lower creatinine clearance and ejection fraction. During
hospitalization, acute pulmonary edema was more frequent in patients with
increased LAVI (14.1% vs. 4.3%, p = 0.024). After discharge, the occurrence of
combined outcome for MCE was higher (p = 0.001) in the group with increased LAVI
(26%) as compared to the normal LAVI group (7%) [RR (95% CI) = 3.46
(1.54-7.73) vs. 0.80 (0.69-0.92)]. After Cox regression, increased LAVI
increased the probability of MCE (HR = 3.08, 95% CI = 1.28-7.40, p = 0.012).ConclusionIncreased LAVI is an important predictor of MCE in a one-year follow-up.
Background: Despite abundant evidence of increased morbidity and mortality, chronotropic incompetence (CI) is not a routine diagnosis well defined in protocols of cardiac evaluation and its clinical importance is still underestimated.
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