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Most of the HCV transmissions result from parenteral exposure. However, there is evidence to suggest a role for sex and household contact with an infected subject in virus transmission.

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This technique allows the adequate oncologic treatment associated with a satisfactory aesthetic result, with precision, in a single surgical time, reducing time and costs.

At least 1 variation in ACP anatomy was found in 38.7% of cases with this simple method. Thus, a preoperative computed tomography scan could improve surgical procedures that involve removal of the anterior clinoid process.

Introduction: Cryptococcus neoformans and Cryptococcus gattii are encapsulated basidiomycetous yeasts with worldwide distribution. They cause cryptococcosis with features of systemic infection, affecting the central nervous system, lungs and skin in humans and animals. These fungi present numerous virulence factors that allow them to invade the host and multiply, among which extracellular enzyme capacity and microbial adaptation to different temperatures are worth mentioning. Objective: To evaluate the production of protease and investigate possible differences in thermotolerance and urease activity in clinical and environmental yeast isolates. Material and methods: Culture methods and Pz analysis were applied to assess urease and protease, whereas the optical density method was used to analyze biological activity in thermotolerance. Results: There was no significant results as to microbial growth at the tested temperatures (25º, 37º and 42ºC). It was observed that clinical specimens grew better than environmental ones at elevated temperatures. As to C. neoformans, the moderate production of urease enzyme prevailed in both clinical and environmental isolates within 24h or 48h. Moreover, there was significant production on the seventh day of reading. The best reading time for viewing protease production in both isolates and species was the seventh day: 96% clinical samples and 94% environmental isolates. Conclusion: Further studies are required in order to investigate the virulence factors of C. neoformans and C. gattii cerebrospinal isolates from patients with meningoencephalitis and environmental samples from Sergipe. Furthermore, a higher technical accuracy and statistical precision are indispensable.

Background Immediate relief following radiosurgery for trigeminal neuralgia (TN) has been observed in a minority of cases. Objective Our goals were to determine the occurrence of immediate pain relief as real vs. placebo effect and to search for factors associated with this desirable outcome. Methods Between January 2003 and June 2008, 150 patients were treated with radiosurgery for classical or symptomatic TN. A commercially available linear accelerator (Novalis®, BrainLab) device was used to deliver 90 Gy to the root-entry zone with a 4- or 5-mm collimator. Pain outcomes were graded using a four-point scale. Complications were recorded through standardized follow-up evaluations. Treatment plans were retrieved and brainstem/trigeminal nerves were retrospectively re-contoured using standard anatomical landmarks. Dose-volume histograms were used to calculate the volume of brainstem/trigeminal nerve receiving 20%, 30%, and 50% of the prescribed radiation doses. Results Twenty-five (19.84%) patients presented with immediate pain relief, defined as pain cessation within 48 hours post-radiosurgery. Kaplan-Meier analysis showed that good/excellent pain outcomes were sustained and significantly better in the immediate pain relief group ( p = 0.006) compared to non-immediate relief. Univariate and multivariate logistic regression analyses failed to show the correlation between brainstem/trigeminal nerve volumes, trigeminal nerve-pontine angle, prior surgical procedures, TN etiology, age, gender, and immediate pain relief. Neither post-radiosurgery complications nor recurrence rates were different between groups. Conclusion Immediate pain relief leads to sustained relief and patients present significantly better pain outcomes in comparison to those without immediate relief. The mechanism triggering immediate relief is still unknown and did not correlate with the volume of brainstem/trigeminal nerve receiving pre-specified doses of radiation.

OBJECTIVEThe proximity of the spinal cord to compressive metastatic lesions limits radiosurgical dosing. Open surgery is used to create safe margins around the spinal cord prior to spinal stereotactic radiosurgery (SSRS) but carries the risk of potential surgical morbidity and interruption of systemic oncological treatment. Spinal laser interstitial thermotherapy (SLITT) in conjunction with SSRS provides local control with less morbidity and a shorter interval to resume systemic treatment. The authors present a comparison between SLITT and open surgery in patients with metastatic thoracic epidural spinal cord compression to determine the advantages and disadvantages of each method.METHODSThis is a matched-group design study comprising patients from a single institution with metastatic thoracic epidural spinal cord compression that was treated either with SLITT or open surgery. The two cohorts defined by the surgical treatment comprised patients with epidural spinal cord compression (ESCC) scores of 1c or higher and were deemed suitable for either treatment. Demographics, pre- and postoperative ESCC scores, histology, morbidity, hospital length of stay (LOS), complications, time to radiotherapy, time to resume systemic therapy, progression-free survival (PFS), and overall survival (OS) were compared between groups.RESULTSEighty patients were included in this analysis, 40 in each group. Patients were treated between January 2010 and December 2016. There was no significant difference in demographics or clinical characteristics between the cohorts. The SLITT cohort had a smaller postoperative decrease in the extent of ESCC but a lower estimated blood loss (117 vs 1331 ml, p < 0.001), shorter LOS (3.4 vs 9 days, p < 0.001), lower overall complication rate (5% vs 35%, p = 0.003), fewer days until radiotherapy or SSRS (7.8 vs 35.9, p < 0.001), and systemic treatment (24.7 vs 59 days, p = 0.015). PFS and OS were similar between groups (p = 0.510 and p = 0.868, respectively).CONCLUSIONSThe authors’ results have shown that SLITT plus XRT is not inferior to open decompression surgery plus XRT in regard to local control, with a lower rate of complications and faster resumption of oncological treatment. A prospective randomized controlled study is needed to compare SLITT with open decompressive surgery for ESCC.