The Apgar score proved linked to factors both epidemiological and related to attention given to the birth and neonatal mortality, and was associated with extremely low birth weight.

We have performed a retrospective study to determine if patients with antiphospholipid syndrome that developed systemic lupus erythematosus (APS/SLE) had distinct clinical and/or serological features. All 80 primary APS (PAPS) patients followed up at our APS unit were included in the study and divided into two groups: 14 APS/SLE and 66 PAPS. Prior or at onset of lupus manifestations, six patients were uniformly negative for lupus and Sjögren autoantibodies, and the other eight patients had persistent positive. In the first year after diagnosis of SLE, three patients remained with negative antibodies, the other seven patients maintained the same antibodies, and four patients developed other antibodies. APS/SLE group had a significant lower mean age at PAPS diagnosis (26.0 ± 8.0 vs. 34.2 ± 11.9 years, p = 0.03) and a longer disease duration (14.0 ± 7.0 vs. 6.0 ± 5.0 years, p < 0.0001). The mean time for PAPS to develop SLE was 5.2 ± 4.3 years. The typical clinical and laboratorial findings of APS did not discriminate both groups of patients. At lupus onset, antinuclear antibodies were more frequently observed in those who evolved to SLE (100 vs. 51.5%, p = 0.0005). Anti-double-stranded DNA (dsDNA), anti-ribosomal P, anti-Ro/SS-A, anti-La/SS-B, and anti-U1RNP antibodies were exclusively found in the APS/SLE patients, whereas anti-Smith (Sm) antibodies were not detected in both groups. The detection of a distinct subgroup of lupus-associated autoantibody in PAPS patients seems to be a hint to overt SLE disease, particularly in those patients with young age at diagnosis.

OBJETIVO: Analisar a cobertura vacinal das crianças durante a segunda etapa da Campanha Nacional de Multivacinação em Unidades Básicas de Saúde (UBS), comparando as diferentes regiões do município de São Paulo. MÉTODOS: Levantamento quantitativo e qualitativo de variáveis referentes às crianças imunizadas durante a vacinação realizada no dia 20/08/2005. Utilizou-se questionário padronizado para a coleta dos seguintes dados: idade, gênero, motivo do atraso vacinal, modo como foi informado da campanha e conhecimento dos responsáveis sobre o intuito da vacinação contra poliomielite. A amostra compreendeu 401 crianças de zero a cinco anos das regiões Norte, Sul, Leste e Oeste da cidade de São Paulo. Foi aplicado o teste de Mann-Whitney, para comparar as idades das crianças de acordo com o gênero, e o qui-quadrado, para verificar a associação entre as regiões municipais, gênero, idade e atraso vacinal. RESULTADOS: A cobertura da segunda etapa da Campanha, de acordo com dados fornecidos pelo Ministério da Saúde, foi de 84,7% - aquém do preconizado. Nossos resultados mostraram que a região Leste apresentou mais crianças com atraso vacinal, justificado pelo difícil acesso à UBS. A televisão foi o meio de divulgação mais eficiente e o médico, o menos. CONCLUSÕES: Existem bolsões de baixa cobertura vacinal. Nenhuma das regiões estudadas atingiu a meta preconizada pelo Programa Nacional de Imunizações (100%). Os gestores locais e os profissionais de saúde devem ser sensibilizados quanto à importância da Campanha.

To compare clinical and laboratory findings between patients with primary antiphospholipid syndrome (PAPS) versus secondary APS due to rheumatic fever (APS-RF) (according to Jones criteria). Seventy-three APS patients (Sapporo criteria) were enrolled, and demographic, clinical, and laboratory data were collected. Exclusion criteria were heart congenital abnormalities and previous infectious endocarditis. Patients were divided into two groups: PAPS (n = 68) and APS-RF (n = 5). The mean current age, disease duration, frequencies of female gender, and Caucasian race were similar in APS-RF and PAPS patients (P > 0.05). Remarkably, the frequency of stroke was significantly higher in APS-RF compared to PAPS patients (80% vs. 25%, P = 0.02). Of note, echocardiogram of these patients did not show intracardiac thrombus. No significant differences were found in peripheral thromboembolic events (P = 1.0), pulmonary thromboembolism (P = 1.0), miscarriage (P = 0.16), thrombocytopenia (P = 0.36), arterial events (P = 0.58), and thrombosis of small vessels (P = 1.0). There were no differences in the frequencies of comorbidities such as diabetes mellitus, hypertension, smoking, and hyperlipidemia in both groups (P > 0.05). The frequencies of lupus anticoagulant, IgG, and IgM anticardiolipin were similar in two groups. APS patients associated with rheumatic fever without infective endocarditis may imply a high stroke risk as compared with PAPS, and future studies are needed to confirm this finding.

Freire et al.: The role of sulfonylurea plus basal insulin on glycemic variability compared to basal bolus regime in T2D patients. Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A66.