Oral mucositis is a painful condition that occurs in patients who have undergone haematopoietic stem-cell transplantation (HSCT) and has a huge impact on their quality of life. The objective of this study was to examine the extent to which interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) are associated with oral health quality of life among patients who underwent HSCT. A. C. Camargo Cancer Center patients were evaluated over 20 months at 4 different time-points: a) at patient admission (M1); b) on the day of infusion of HSC (M2); c) 12 and 20 days after the first day of the conditioning regimen for autologous and allogeneic transplantation, respectively (M3); and d) 30 days after the first day of the conditioning regimen (M4). Mucositis clinical evaluations were performed using World Health Organization (WHO) criteria. Oral health quality of life was measured using the Oral Health Impact Profile short form (OHIP-14), Oral Mucositis Quality of Life (OMQoL) and Patient-Reported Oral Mucositis Symptom (PROMS) scales. Correlations between clinical data and quality of life scores were examined. STATA 11.0 was used to perform the statistical analyses (5% level of significance). Eighty-two patients participated in the study; 62.2% were male, 28.05% had multiple myeloma, and the mean age was 48.49 years (SD 13.76). Higher scores (worse quality of life) were observed as mucositis scores increased, but the results were not significant. The OMQoL had a high correlation with OHIP-14 (0.8377), but the correlation between the PROMS scale and the OHIP-14 was lower (0.6643). Higher concentrations of IL-6 and TNF-α were associated with worse quality of life, according to all indices (p < 0.05). Oral mucositis was associated with quality of life scores (p < 0.01).

INTRODUCTION : With the interest in anticipating access to the result of intraoral radiography, the radiographic processing is frequently neglected, compromising image quality. OBJECTIVE : The aim of this study was to evaluate the influence of interrupting the fixation process on the radiographic contrast and base-plus-fog density (BPFD) in three brands of periapical films. MATERIAL AND METHOD : Ninety radiographs were taken of an aluminum stepwedge and a lead plate for each brand, and they were divided according to the time of initial immersion in the fixative in: control group (without interrupting the fixing), 5, 10, 20, 30 and 40 seconds. During processing, films had the fixing stage stopped and were exposed to a negatoscope for 1 minute, then the fixation time of 10 minutes was completed. The radiographs were digitized and exported to Image Tool 3.0.software. RESULT : Kodak(r) film showed no statistically significant differences between groups, while Agfa(r) film presented difference in BPFD compared with Group 5 seconds, and Dentix(r) film showed statistical difference in all groups in comparison with the control group. CONCLUSION : Under the conditions studied, Kodak(r) film is not influenced by disruption of fixation as regards BPFD and image contrast, enabling early access to the results of radiographs, whereas Agfa(r) film requires at least 10 seconds of initial fixation, and Dentix(r) film obtains better results when the process of fixation is not interrupted.

Objetivo: A Subtração Radiográfica Digital (SRD) é uma técnica utilizada para comparar duas radiografias de um mesmo objeto, realizadas em diferentes momentos, para demonstrar a existência de diferenças entre elas. Contudo, a reprodutibilidade da geometria de relação entre objeto, filme e fonte de raios X é indispensável para evitar a formação de ruídos estruturais. O objetivo deste trabalho foi comparar a aplicação de diferentes métodos de registros (a priori e a posteriori), em diferentes tempos de exposição (0,2 e 0,4 segundos), na produção de ruído estrutural em imagens subtraídas. Método: dez mandíbulas foram radiografadas em duas situações: com uso de posicionadores convencionais sem registro e com registro a priori, sendo que ambos os métodos foram reproduzidos após 15 dias. O registro a posteriori foi realizado por meio do programa Regeemy ® 0.2.43, e a subtração no programa Image Tool ® 3.0. O ruído estrutural foi quantificado pelo programa Adobe Photoshop ® 7.0, que fornece valores de desvio padrão dos níveis de cinza na região de interesse (ROI). Esses valores foram submetidos à análise estatística ANOVA e teste Tukey a 5% de significância. Resultados: no tempo de exposição 0,4 s, os grupos obtiveram valores menores de desvio padrão em relação ao tempo de 0,2 s. Os grupos com registro a posteriori e a priori associados tiveram os menores valores de desvio padrão, seguidos pelos grupos com registro a posteriori. Conclusão: nas condições estudadas, o tempo de 0,4 s foi o mais adequado e a utilização do registro a posteriori foi essencial na formação de imagens subtraídas com baixo ruído estrutural.

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