A large number of diseases may cause Atrophic skin disorders are caused by a large
number of diseases, some of them idiopathic and others inflammatory, in which there
is loss of volume of body segments. Localized scleroderma is a rare inflammatory
dermatosis, manifested by atrophic skin and subcutaneous tissue alterations.
Lipoatrophy may be genetically inherited or acquired as a result of panniculitis, HIV
infections or aging. Many treatments have been proposed. Results vary in the acute
inflammatory phase and are scarce when sclerosis and atrophy have already been
established. This article describes four cases of localized facial scleroderma and
one of facial idiopathic lipoatrophy treated with implantation of autologous fat
globules extracted from the infragluteal groove, without utilization of cannula
aspiration, with lasting results.
Background
Diabetic cutaneous ulcers are subjected to several physiological and biochemical defects, which contribute to wound chronicity and therapeutic failure. Platelet‐rich plasma (PRP) has been used for stimulating tissue regeneration, and mesenchymal stromal cells (MSCs) have demonstrated therapeutic properties in all phases of skin regeneration in cell therapy studies.
Aims
The objective of this study was to evaluate the therapeutic effects related to the use of a biomembrane composed of autologous MSCs and PRP on chronic wounds of diabetic patients (pre‐post pilot study).
Patients/Methods
Six diabetic patients with chronic wounds for more than 6 months were subjected to adipose tissue collection for isolation of MSCs, blood collection for PRP preparation, and topical administration of a biomembrane of MSCs and PRP on each chronic wound. The statistical difference regarding the evolution of ulcers was calculated by means of paired t test.
Results
There was granulation tissue formation starting from 7 days after topical application. Total re‐epithelialization occurred in 5 of the 9 lesions treated, and the mean wound healing rate (WHR) was 74.55% (±32.55%) after 90 days. No cicatricial hypertrophy or retraction was observed.
Conclusion
Mesenchymal stromal cells topical therapy associated with PRP is well‐tolerated and able to provide a reduction in ulcer area of diabetic chronic wounds.
Patients with scleroderma, especially those with CREST syndrome, are predisposed to develop chronic skin wounds. These wounds are difficult to treat and directly affect the quality of life of these patients. Thus, the present study evaluated the use of autologous fibroblasts for the treatment of wounds caused by calcium deposition typical of CREST syndrome pathology.
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