UC patients with PSC show a propensity for more extensive, but less active, disease but are otherwise characterized by similar pathologic findings compared with UC patients without PSC. Rectal sparing and patchy disease activity is not characteristic of UC patients with PSC.
This study showed that FDG-PET tumor segmentation-derived indices of metabolic activity play a definite role in the evaluation of response to neoadjuvant chemoradiotherapy and progression-free survival in patients with esophageal cancer.
Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose people to renal cancer, hemangioblastomas, and pheochromocytomas in an allele-specific manner. The best documented function of the VHL gene product (pVHL) relates to its ability to polyubiquitinate, and hence target for destruction, the ␣ subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF). pVHL mutants linked to familial pheochromocyctoma (type 2C VHL disease), in contrast to classical VHL disease, appear to be normal with respect to HIF regulation. Using a simple method for identifying proteins that are differentially secreted by isogenic cell line pairs, we confirmed that the HIF targets IGBP3 and PAI-1 are overproduced by pVHLdefective renal carcinoma cells. In addition, cells lacking wild-type pVHL, including cells producing type 2C pVHL mutants, were defective with respect to expression and secretion of clusterin, which does not behave like a HIF target. Decreased clusterin secretion by pVHL-defective tumors was confirmed in vivo by immunohistochemistry. Therefore, clusterin is a secreted marker for a HIF-independent pVHL function that might be especially important in pheochromocytoma development. von Hippel-Lindau disease, caused by heterozygous germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene, presents clinically as a hereditary cancer syndrome.1,2 Tumor development in this setting is due to somatic inactivation of the remaining wild-type VHL allele in a susceptible cell.3 The classical tumors observed in VHL disease are retinal and central nervous system (usually within the cerebellum or spinal cord) blood vessel proliferations called hemangioblastomas. These tumors, although benign, cause significant morbidity and mortality because of mass effect. Some VHL families also exhibit an increased risk of clear cell renal cell carcinoma or pheochromocytoma. In keeping with the Knudson 2-hit model, many sporadic hemangioblastomas and renal cell carcinomas are also due to VHL inactivation, as a result of either somatic mutations or hypermethylation.3,4 For reasons that are still unclear, somatic VHL mutations are rare in sporadic pheochromocytomas absent an occult germline VHL mutation, despite the fact that certain germline VHL mutations confer an increased risk of this tumor.Genotype-phenotype correlations have emerged in VHL disease. VHL families can be subdivided into type 1 (low risk of pheochromocytoma) and type 2 (high risk of pheochromocytoma). Type 2 disease can be subdivided into type 2A (low risk of renal cell carcinoma) and type 2B (high risk of renal cell carcinoma).1 Some VHL families exhibit an increased risk of pheochromocytoma without Supported in part by grants from the National Institutes of Health (to W.G.K.), the Kurozumi Medical Foundation (to E.N.), the Japanese Clinical Oncology Fund (to E.N.), the Ministry of Education, Culture, Sports, Science and Technology of Japan (to E.N. and O.O.), and the Murray Foundation (to W.G.K.
FDG-PET-derived tumor metabolic length of untreated esophageal carcinomas correlates well with surgical pathology results, and provides preliminary evidence that noninvasive delineation of the superior and inferior extent of viable tumor involvement might be feasible using computer-generated metabolic length measurements.
5Introdução: O carcinoma papilífero é o tipo mais comum de câncer da tireoide e a tireoidite de Hashimoto é a causa mais frequente de hipotireoidismo em áreas onde os níveis de iodo são adequados. Vários investigadores detectaram incidência aumentada de carcinoma papilífero da tireoide em pacientes com tireoidite de Hashimoto. Na rotina de diagnósticos histopatológicos há uma aparente associação entre as duas patologias. Objetivo: Determinar a relação entre tireoidite de Hashimoto e carcinoma papilífero de tireoide, avaliando os aspectos histomorfológicos, quando concomitantes ou apresentando-se de forma isolada.
Artigo OriginalSensibilidade e especificidade da core biopsy estereotática no diagnóstico histopatológico das lesões mamárias impalpáveis
The authors report a male infant born at 35 weeks gestational age with an atypical presentation of homozygous alpha-thalassemia. The live-born infant displayed abnormalities of the upper limbs and genitalia, which are vascular-type disruptive defects associated with this disease. Cardiomegaly and placentomegaly were the only evidence of fetal hydrops. Postnatal karyotype revealed mosaicism for trisomy 7, yet another rare finding in a live-born. The authors discuss their institutional experience with each of these rare conditions and the potential contribution of each to the overall unusual clinical presentation in this patient. This is the first report of these simultaneous diagnoses.
Introdução:As displasias da laringe são precursoras do carcinoma escamocelular invasivo e constituem lesões pouco comuns, pois a maior parte dos casos é detectada como carcinoma invasor. Objetivo: Caracterizar as displasias acentuadas/carcinoma in situ da prega vocal quanto a área do epitélio, diâmetro dos núcleos e índice proliferativo, comparando esses dados com os obtidos no epitélio escamoso normal e de transição. Material e método: Entre as 1.400 biópsias e peças cirúrgicas de lesões intraepiteliais e carcinomas invasivos de laringe (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006), foram selecionados cinco casos (0,35%) pareados com dois controles de epitélio normal e com a idade; todos foram submetidos a análise morfométrica e imuno--histoquímica (Ki-67). Resultados: Comparando-se o epitélio displásico com o normal e de transição observou-se maior área e diâmetro nuclear no epitélio displásico; não houve diferenças significativas no diâmetro dos núcleos por camada entre o epitélio displásico e de transição; e o índice proliferativo foi maior no epitélio displásico com núcleos corados em todas camadas e menor com núcleos limitados a camada basal e parabasal no epitélio normal e de transição. Conclusão: verifica-se maior área no epitélio displásico. O diâmetro dos núcleos do epitélio displásico e do de transição são semelhantes, mas este apresenta núcleos uniformes em toda extensão em contraste com o pleomorfismo do epitélio displásico. O índice proliferativo (Ki-67) contribui para o diagnóstico diferencial das lesões escamosas da prega vocal, pois no carcinoma in situ/displasia acentuada observa-se maior número de núcleos marcados, os quais são vistos em todas as camadas no epitélio. resumo unitermos Laringe Carcinoma in situ Prega vocal Antígeno Ki-67abstract Introduction: Laryngeal dysplasias, precursors of squamous cell carcinomas, are uncommon lesions, inasmuch as most cases are diagnosed as invasive carcinomas. Objective: To characterize severe dysplasia/in situ carcinoma of the vocal cords by comparing the area of involved epithelium, nuclear diameter, and proliferative index with transition and normal squamous epithelia. Material and method: Among 1,400 surgical and biopsy specimens of laryngeal lesions (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006), five cases (0.35%) were selected and compared according to age with two controls with normal epithelium. Furthermore, all of them were identified and submitted to morphometric and immunohistochemical analysis . Results: After comparing dysplastic with transition and normal squamous epithelia, it was observed an increased nuclear diameter in dysplastic epithelium. Additionally, there was no significant difference in nuclear diameter per layer between dysplastic and transition epithelia. Moreover, the proliferative index was higher in dysplastic epithelium with stained nuclei in all layers and lower in normal and transition epithelia with nuclei concentrated on the basal and parabasal layers. Con...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.