Personality psychologists from a variety of theoretical perspectives have recently concluded that personality traits can be summarized in terms of a 5-factor model. This article describes the NEO Personality Inventory (NEO-PI), a measure of these 5 factors and some of the traits that define them, and its use in clinical practice. Recent studies suggest that NEO-PI scales are reliable and valid in clinical samples as in normal samples. The use of self-report personality measures in clinical samples is discussed, and data from 117 "normal" adult men and women are presented to show links between the NEO-PI scales and psychopathology as measured by Jackson's (1989) Basic Personality Inventory and Morey's (1991) Personality Assessment Inventory. We argue that the NEO-PI may be useful to clinicians in understanding the patient, formulating a diagnosis, establishing rapport, developing insight, anticipating the course of therapy, and selecting the optimal form of treatment for the patient.In the past two decades there has been remarkable progress in one of the oldest branches of personality psychology: the study of traits or individual differences. The conceptual status of traits has been clarified (Costa & McCrae, 1980;Funder, 1991; Tellegen, in press), and trait measures have shown evidence of convergent and discriminant validity across instruments (McCrae, 1989) and observers (Kenrick & Funder, 1988). Longitudinal studies of both self-reports and ratings have shown impressive stability of a wide range of traits across the adult lifespan (Block, 1981;. Perhaps most exciting is the growing agreement among personality psychologists that most individual differences in personality can be understood in terms of five basic dimensions: Neuroticism (N) vs. Emotional Stability; Extraversion (E) or Surgency; Openness to Experience (O) or Intellect; Agreeableness (A) vs. Antagonism; and Conscientiousness (C) or Will to Achieve (Digman, 1990;John, 1990;Norman, 1963; Wiggins & Trapnell, in press). These factors have been recovered in studies of self-reports and ratings, lay adjectives and standardized questionnaires, adults and children, and several different cultures.This five-factor model is a theoretical advance that has important implications for many applied areas, including clinical practice. By assessing traits from each of the five factors, the clinician can obtain a comprehensive portrait of the client's personality, and the clinical researcher can systematically examine relations between personality and treatment variables. Recent articles and symposia have examined the utility of the five-factor model in counseling , abnormal psychology (Widiger & Trull, in press), and clinical psychology (Spielberger, 1989