Epidendrum mosenii is a Brazilian medicinal plant, traditionally used to treat infective and dolorous processes. The present article reports a comparative study of the chemical and pharmacological aspects of different parts and seasons of this plant. The results demonstrate that 24-methylenecycloartanol (1), one of the main active principles present in this plant, is located practically in all the parts and during all seasons, but it is much more concentrated in the stems when collected in spring and summer. The pharmacological results indicate that dichloromethane extracts collected in spring and summer were the most active when evaluated against the writhing test in mice, being several times more potent than some reference drugs used as comparison. Together, the results strongly suggest that the antinociceptive effect of E. mosenii is related, at least in part, to the presence of compound 1, and this finding could be useful for quality control of phytopreparations based on this plant.
Epidendrum mosenii is a Brazilian medicinal plant, traditionally used to treat infections and pains. This study reports on the chemical composition and microbiological properties of different parts and in different seasons of this plant. Results demonstrate that 4,3',5'-trihydroxy-3-methoxy-dihydrostilbene (1), 4,5-dihydroxy-3,3-dimethoxy-dihydrostilbene (2) and pholidotin (3) were mainly present in the roots in all seasons, and the yield of mass extract increased their recovery in other parts, such as the stem and leaves for compounds (2) and (3), in summer and winter, respectively. The antifungal results indicate that compounds (1) and (2) have interesting activity against Cryptococcus neoformans, Microsporum gypseum, Trychophyton rubrum and Trychophyton mentagrophytes with MIC values between 62.5 and 125 µg/mL. Taken together, these results strongly suggest that the antifungal properties of E. mosenii are related, at least in part, to the presence of dihydrostilbenes 1 and 2, and this is useful for quality control of phytopreparations based on this plant, justifying the popular use of this plant to treat infections.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.