The theory of a5Kr solubility in the body is discussed and a weight partition coefficient, equal to the Ostwald coefficient divided by absorber density, is defined to facilitate study of solubility in intact tissue and dose calculations.In vivo weight partition coefficients were determined in guinea pigs for blood and 22 other organs and tissues using a dual-isotope technique that permits simultaneous determinations for whole and bloodless tissue. The highest coefficients found for bloodless tissue were: omental fat (0.42 1) ; subcutaneous fat (0.405) ; thymus (0.259) ; lymph nodes (0.138) ; bone marrow (0.134); and adrenals (0.102). In general, the in vivo coefficients agreed well with predictions based on in vitro solubility determinations and the fat-protein-water composition of the tissue as reported in the literature.Ostwald coefficients were determined in vitvo for 85Kr into guinea pig blood, guinea pig brain homogenate, dog blood, cat blood, Chinese hamster blood, 0.9% NaCl solution and 10% EDTA solution.
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