ASTRACTObjective: To evaluate whether the obesity alters ultrasonographical markers of
metabolic and cardiovascular disease risk in children.Methods: A cross-sectional study evaluated 80 children aged between 6 and 10 years,
comparing 40 obese with 40 normal children. The following parameters were
assessed: weight; height; body mass index; arterial blood pressure; body
fat; basal metabolic rate; HDL-cholesterol, LDL-cholesterol and total
cholesterol; fasting insulin and glucose; quantitative insulin sensitivity
check index (QUICKI); homeostasis model of assessment - insulin resistance
(HOMA-IR); basal diameter of the brachial artery; brachial artery flow
mediated dilation (FMD) and of pulsatility index change (PI-C).Results: Significant differences were observed between obese vs. non-obese children:
systolic blood pressure (97.7±8.4 vs. 89.0±5.8 mmHg; p<0.01), diastolic
blood pressure (64.3±7.9 vs. 52.9±5.1 mmHg; p<0.01), proportion of body
fat (45.1±5.9 vs. 21.3±6.0%; p<0.01), basal metabolic rate (1216.1±102.1
vs. 1072.9±66.4 Kcal; p<0.01), total cholesterol (164.7±25.2 vs.
153.4±15.8 mg/dL; p=0.03), fasting insulin (7.1±5.2 vs. 2.8±1.8 pIU/mL;
p<0.01), HOMA-IR (1.5±1.1 vs. 0.6±0.4; p<0.01), basal diameter of the
brachial artery (2.5±0.3 vs. 2.1±0.3 mm; p<0.01); PI-C (-15.5±27.2 vs.
-31.9±15.5%; p<0.01), decreased QUICKI (0.4±0.05 vs. 0.4±0.03;
p<0.01), and FMD (6.6±3.2 vs. 15.6±7.3%; p<0.01).Conclusions: Obesity worsens ultrasonographical and laboratorial markers of metabolic and
cardiovascular disease risk in children.
Background: breast milk offers numerous advantages biological and emotional. However, in some situations, can transfer harmful elements for the health of infants.
Objective: to determine lead levels in the blood and milk of mothers whose children frequent a primary mother-child health care.
Methods: a cross-sectional, observational and descriptive study of 70 healthy women who were breast-feeding babies younger than six months during 01/04/2011 to 30/09/2011. Lead determination was performed by mass spectrometry with inductively coupled plasma. A linear regression model was adjusted to determine the association between lead concentrations in maternal milk and blood. The estimated values of the difference between means and their 95% confidence intervals were obtained.
Results: mean lead concentration in milk was 1.462 ng/mL and blood lead concentration was 1.801 μg/dL.
Conclusions: human milk is not a source of contamination for the babies in this area. However, more studies are needed in other regions of the country in view of the growing evidence of foci of lead contamination, which may represent an occult risk for the population.
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