RESUMENSe ha elaborado la primera guía clínica española que permitirá a los farmacéuticos comunitarios y demás profesionales de la salud seleccionar, para cada indicación específica, el producto con probióti-cos adecuado, la dosis y la vía de administración. Con ello se pretende lograr que la práctica diaria de indicación farmacéutica de los suplementos probióticos esté basada en las mejores evidencias científicas disponibles. First clinical guide based on medical evidence for probiotic supplementation in Spanish community pharmacies ABSTRACTWe have developed the first Spanish clinical guide that will allow the community pharmacists and other health care professionals easily select the right product with probiotics, dosage and format for each specific indication. With the proposed guide, it is our goal that the daily pharmaceutical practice of probiotics supplementation in community pharmacy is based on the best scientific evidence available. PALABRAS CLAVEProbióticos, guía de práctica clínica, medicina basada en la evidencia, microbiota, suplementos dietéticos, farmacéutico comunitario Financiación: Ninguna. Contribución a la autoría: Todos los autores han contribuido por igual al diseño de la investigación, su desarrollo, análisis de los datos, redacción del manuscrito y revisión del contenido final. Conflicto de intereses: Ninguno. Cite este artículo como: Fernández N, Cardelle-Cobas A, Regal P, Cepeda A, Fente C. Primera guía clínica basada en la evidencia médica para la suplementación con probióticos en la farmacia comunitaria española.
RESUMENSe ha elaborado la primera guía clínica española que permitirá a los farmacéuticos comunitarios y demás profesionales de la salud seleccionar, para cada indicación específica, el producto con probióti-cos adecuado, la dosis y la vía de administración. Con ello se pretende lograr que la práctica diaria de indicación farmacéutica de los suplementos probióticos esté basada en las mejores evidencias científicas disponibles. First clinical guide based on medical evidence for probiotic supplementation in Spanish community pharmacies ABSTRACTWe have developed the first Spanish clinical guide that will allow the community pharmacists and other health care professionals easily select the right product with probiotics, dosage and format for each specific indication. With the proposed guide, it is our goal that the daily pharmaceutical practice of probiotics supplementation in community pharmacy is based on the best scientific evidence available. PALABRAS CLAVEProbióticos, guía de práctica clínica, medicina basada en la evidencia, microbiota, suplementos dietéticos, farmacéutico comunitario Financiación: Ninguna. Contribución a la autoría: Todos los autores han contribuido por igual al diseño de la investigación, su desarrollo, análisis de los datos, redacción del manuscrito y revisión del contenido final. Conflicto de intereses: Ninguno. Cite este artículo como: Fernández N, Cardelle-Cobas A, Regal P, Cepeda A, Fente C. Primera guía clínica basada en la evidencia médica para la suplementación con probióticos en la farmacia comunitaria española.
Mycotoxins are natural compounds produced as secondary metabolites by a wide variety of different species of filamentous fungi. One of the most important groups in terms of occurrence and toxicity is the group of aflatoxins (AFs). The major members of this group are aflatoxin B1, B2, G1, G2, M1 and M2. Exposure to AFs can cause chronic and acute toxic effects, as they can be carcinogenic, mutagenic, teratogenic and immunosuppressive. AFB1 is considered as the strongest carcinogen of natural origin and it is normally predominant in crops and their derived products. Aflatoxin M1 is the main metabolite of aflatoxin B1 in humans and animals and as such it may be present in milk from animals fed with contaminated feed. Although the toxicity of M1 is about ten times lower than for B1, it also has hepatotoxic and carcinogenic effects. For the analysis of mycotoxins in cereals and/or milk, IAC in combination with HPLC are increasingly used as reference method due to their high selectivity and good elimination of matrix interferences. However, the cost of analysis using IAC is usually high. In recent years, molecularly imprinted polymers (MIP) have become very popular and promising materials for extracting different analytes in several matrices. AFs are too toxic to be used in MIP preparation, and template bleeding may be an additional problem, especially when dealing with very low levels. For this reason, in this study the use of a dummy template was preferred for MIP synthesis. A rapid, affordable and selective extraction method based on magnetic MIPs (MMIP) has been developed for the isolation of aflatoxins (B1, B2, G1, G2, M1), using a combination of imprinted polymers and magnetite. The successful MMIP stirring "cake" (used as a stir-bar) has been combined with HPLC-MS/MS for the determination of AFM1 in milk powder (infant formulas) to demonstrate its applicability to real samples.
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