<p>This research studied the relationship between entrepreneurship education and entrepreneurial intention of university students. Following original research by Zhang, Duysters, Cloodt (2014), Ajzen's theory of planned behavior and Shapero's entrepreneurial event model would be incorporated to identify the effect of exogenous variables such as entrepreneurship education, prior entrepreneurial exposure, perceived desirability and feasibility towards entrepreneurial intention in university students. Furthermore, this study aimed to investigate the selection hypothesis of entrepreneurship education for entrepreneurial intentions. Lastly, this study was also proposing to investigate the moderating effect of the teachers and instructors' enthusiasm (Frenzel et al., 2009), pre-educational entrepreneurship intention (Bae et al., 2014), gender (Verheul et al., 2012), as well as the moderating effect of peers in the classroom (Falck et al., 2012). The data would be collected from one of the private and reputable universities in Indonesia in multiple departments with a form of entrepreneurship education. In this study we found that entrepreneurship education does shape entrepreneurial intention. Students with pre-educational entrepreneurial intention would be more likely to have higher entrepreneurial intention. We also learned that there’s a strong relationship between social influence of classmates and entrepreneurial intention. In addition, we found that male and female students have a different perspective about entrepreneurship education that affected their entrepreneurial intention.</p>
Entrepreneurship in Indonesia has been developing rapidly these past years. A survey among 210 university students without economic or business educational background showed that they also have an intention to be an entrepreneur and that their major in the university is not a barrier for them to start their own business. This study uses three independent variables which are attitude toward behavior, perceived behavioral control, and subjective norms to see the impact towards students' entrepreneurial intention. Data was processed using PLS-SEM (Partial Least Square-Structural Equation Modeling). The finding of this study showed that attitude toward behavior, perceived behavioral control, and subjective norms have a significant impact towards students' entrepreneurial intention. This study can be used by the government and universities to create programs that will increase the entrepreneurial spirit among students from various educational background and open opportunities for them to participate in entrepreneurial activities.
Background: The treatment of betel-nuts related HNSCC in Taiwan is challenging and related to strong inflammation, invasion, and angiogenesis. In our previous studies, betel-nuts related TW2.6(p53 defective mutation, p16 loss, BCL2þ) was resistant to chemotherapies, radiation, and EGFR inhibitors. In addition to PI3K/mTOR dual inhibition, polo-like kinase inhibitor with radiation, CDK4/6 inhibitor, WEE1 inhibitor, ALK/IGF-1R inhibitor, Bcl2 inhibitor, and eribulin, Astragalus polysaccharides, FGFR inhibitor, CDK4/6 inhibitor, & VEGFR2/FGFR/PDGFR or VEGFR2/c-MET/Axl triple blockage could reverse treatment refractoriness, through the inhibition of mesenchymal transformation & PI3K/Akt/mTOR signaling and the modulation of stemness & PD1/PDL1 pathway. DNA damage response is important in HNSCC tumorigenesis and DDR interventions may enhance tumor antigen presentations and immuotherapy. Purpose: We try to find out DDR interventions in betel-nus related HNSCC. Methods: Polo-like kinase inhibitor, WEE1 inhibitor, PARP inhibitor, and ATR inhibitor were tested on TW2.6 to evaluate (1)the in vitro drug sensitivity; (2)synergistic effects with some chemotherapies and target therapies with MTT assay, colon formation assay, flow cytometry, and western blotting. Results: Volasertib, AZD1775, and foretinib(VEGFR/c-MET/Axl triple inhibitor) could reverse TW2.6 resistance to olaparib. AZD1775 was effective on TW2.6 and could also resensitize docetaxel and enhance further eribulin effects. AZD6738 was effective on TW2.6 and caused (1)several mesenchymal differentiation markers(esp. Twist) drop; (2)p70S6K drop but p-AKT increase; (3)prominent PDL1 & mild BMI-1 drop. Conclusions: TW2.6 might reflect treatment refractoriness of betel-nuts related HNSCC in Taiwan. TW2.6 resistance to PARP inhibitor could be handled by PLK1, WEE1, or c-MET inhibition. WEE1 inhibitor could reverse docetaxel resistance. Novel ATR inhibitor mechanisms and combinations(with PI3K inhibitor) should be searched.
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