Prosody is defined as the melodic line of language. In this study we included 25 patients with probable Alzheimer''s disease and 14 with multi-infarct dementia for a comparative cross-sectional study of prosody. Neuropsychological analysis was based on Mini-Mental test, Blessed Scale and Clinical Dementia Rating. We used the criteria of Monrad-Krohn to evaluate prosodic categories. We found intrinsic aprosody in 8 patients with Alzheimer''s disease and in none of the patients with multi-infarct dementia (prevalence ratio: 1.82, 95% CI: 1.32–2.51), and emotional aprosody in 17 patients with Alzheimer''s disease in comparison to 4 with multi-infarct dementia (prevalence ratio: 1.8, 95% CI: 1.04–3.18). The differences in intellectual and inarticulate aprosody were not significant. We conclude that aprosody is more frequent and severe in Alzheimer''s disease than in multi-infarct dementia.
It describes dysphagia secondary to metastatic involvement of the esophagogastric junction, in a clinical case with several poorly described relationships: dementianeoplasia of pancreatic tail-infiltration of the esophagogastric junction.
Clinical imagesA 93-year-old woman referred from a nursing home by weight loss, fatigue, dysphagia for solids and liquids and sialorrhea after swallowing from 6 months ago. In recent weeks, epigastralgia associated with intakes. As medical history: left hip fracture 2 years ago, moderatestage dementia with recent memory impairment of more than 2 years of evolution. She walks short routes with walker, precise help for rest of basic activities of daily living. Physical examination, with no significant findings. No analytical alterations. Tumor markers, negative. Abdominal CT with intravenous contrast in arterial and portal venous phases: infiltrating mass compatible with primary pancreatic tail neoplasia ( Figure A), with left paraaortic adenopathies and extensive gastric, esophagogastric junction ( Figure B) and visceral perivascular infiltrations. During her stay the patient presents hypoactive delirium, inability oral feeding, vomiting of bilious and undigested food content, with a good response to haloperidol [1]. Moved to Palliative Care Unit for control and management of symptoms.
ConclusionIt is important to assume that, in patients with dementia who suffer from dysphagia, the etiology is not just neurogenic. In this case, it describes dysphagia secondary to metastatic involvement of the esophagogastric junction, in the inverse association between cancer and neurodegenerative disease [2].
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