background. Patients with prominent periorbital fat pads often complain of having a persistent "tired" look and seek treatment from their dermatologist. objective. A non-surgical treatment of fat pads. methods. Thirty patients were treated for prominent lower eyelid fat pads with phosphatidylcholine injection. Pre-and posttreatment photographs were taken for long-term analysis.results. A marked reduction of the lower eyelid fat pads was noted over the 2-year follow-up period. There were no recurrences. conclusion. The injection of phosphatidylcholine (250 mg/5 ml) into the fat pads is a simple office procedure that may postpone or even substitute for lower eyelid blepharoplasty.

Necrosis of the fat cells in all the phosphatidylcholine-injected animals was observed. Further studies should be performed to clarify and determine the mechanisms of action.

The injection of phosphatidylcholine (250 mg/5 ml) into the fat pads is a simple office procedure that may postpone or even substitute for lower eyelid blepharoplasty.

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Abstract. Subjects with localized fat deposits commonly receive suction lipectomy as a cosmetic procedure. A new office procedure for correction of those superficial fat deposits was applied in 50 patients by injection of phosphatidylcholine. The method itself consists of using a 3OG1/2 insulin needle to inject about 5 ml (250 mg/5 ml) of phosphatidylcholine into the fat, distributing it evenly in an 80-cm 2 area. Pre-and posttreatment photographs were taken for technical planning and analysis of the results over the long term. A clear improvement occurred in all, with a marked reduction of the fat deposits without recurrence over a 2-year follow-up period and no weight gain. The injection of phosphatidylcholine into the fat deposits is a simple office procedure that can sometimes postpone or even replace surgery and liposuction.

The lack of any reported general complications after injection lipolysis with Lipostabil Endovena is encouraging. However, larger studies are needed to confirm that the use of Lipostabil Endovena is safe.

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