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Mycobacterium tuberculosis infection is a common infection in developing countries, including India. It can induce several cutaneous reactions such as erythema nodosum, and erythema induratum; however, association of tuberculosis with Sweet's syndrome (also known as acute febrile neutrophilic dermatosis) is extremely rare. Here we present an interesting case of sputum-positive pulmonary tuberculosis with Sweet's syndrome. A 55-year-old female who was receiving a regimen of four antitubercular drugs (isoniazid, rifampicin, pyrazinamide, ethambutol-HRZE) for six weeks for sputum-positive pulmonary tuberculosis developed new onset high-grade fever for 15 days along with multiple reddish brown plaques and nodules involving the face as well as all four limbs of the body. Histopathology of the skin lesion was suggestive of Sweet's syndrome. The patient responded well to immunosuppressive steroid therapy.

Cap polyposis is a gastrointestinal disease with multiple inflammatory polyps between the distal colon and rectum. Its symptoms overlap with inflammatory bowel disease with typical endoscopic features of multiple sessile polyps in the rectum and sigmoid colon, located at the apices of transverse folds. Microscopically, the polyps consist of elongated, tortuous, and distended crypts covered by a “cap” of inflammatory granulation tissue. In this report, we present a case of a 18-year-old male patient who underwent polypectomy for polyposis in multiple settings. He presented with one year of painless rectal bleeding and polyposis in a recto-sigmoid area on colonoscopy, with a single polyp in the sigmoid area and multiple polyps in the rectum. He was managed with immediate and interval polypectomy. Though cap polyposis is rare, it can be cured as it is laparoscopically resectable.

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Background: Stroke is the second most common cause of mortality in the world, causing immense morbidity and economic burden. The proper knowledge of the factors which influence the good clinical outcome in stroke is utmost strength of the clinicians in India, where post stroke rehabilitative measures are limited.Aims and Objective: To find out the association of outcome of stroke with different risk factors.Materials and Methods: A descriptive observational design study was formulated for a period of six months on hundred stroke patients in internal medicine unit of at North Bengal Medical College & Hospital, India. Patients were selected after proper screening by inclusion and exclusion criteria. The “In-hospital-outcome” of CVA patient was determined by Glasgow outcome scale. The neurological condition was determined by National Institute of Health Stroke Scale (NIHSS). The Modified Rankin Scale and Barthel Index were utilized to asses disability status of patient in different period of hospital admission. The data were analyzed by EPI INFO software.Results: Clinical outcome showed statistically significant (P<0.05) correlation with age, sex, level of consciousness, blood pressure, diabetes, past history, mass effect, size and depth of infarction and intra-ventricular extension of intra cerebral bleeding. Other parameters like type of stroke (ischemic or hemorrhagic), delay in admission, dyslipidemia, presence of heart disease, smoking, alcoholism, family history, depth and volume of intra cerebral bleeding, although showed poorer clinical outcome, their correlation was not statistically significant.Conclusion: In-hospital outcome of stroke as determined by Glasgow outcome scale correlates with diverse clinical parameters including various risk factors.Asian Journal of Medical Sciences Vol.9(4) 2018 1-9

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Background: Opportunistic Infections in HIV are major determinants of mortality in HIV patients. Tuberculosis is a leading cause of mortality. Tuberculosis is a public health challenge specially in developing countries like India. The incidence of TB HIVco-infection is gradually increasing. Methods: This was institution based, retrospective study. Study was conducted at ART Centre, North Bengal Medical College & Hospital, Sushruta Nagar, Darjeeling, West Bengal from January 2015 to January 2020 including 105 HIV-TB co-infected patients. Data was collected and template was generated in MS excel sheet and analysis was done on SPSS software. Results: 105, HIV-TB co-infected patients were registered with majority being male (n=79), mean age for male and female patients were 36.78 years and 35.73 years respectively.. The number of patients diagnosed with Extra-pulmonary tuberculosis (EPTB) and Pulmonary tuberculosis (PTB) were almost equal. Majority of patients (34.3%) had CD4 counts <200 whereas (33.3%) had CD4 counts between 200-349. Favourable outcome in terms of cured patients were 82.85% with a statistically signicant pre-treatment and post-treatment improvement in body weight (p value<0.0001) and CD4 count (p value<0.002. Conclusions: There is a strong association between incidence of TB and HIV infection. Early diagnosis and treatment are essential to reduce mortality and morbidity in people living with HIV. Strict adherence to treatment and dedicated counseling for drug compliance is the need of the hour.