The combination of low-dose spironolactone with metformin seems superior to either drug alone in terms of clinical benefits and compliance in women with PCOS.

No abstract

Background: Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy. CTS is more common in the age group of 45-65 years and more common in women than men.  Several factors cause CTS, including pregnancy and lactation.Methods: The study was conducted on 60 females with carpal tunnel syndrome. Each patient was subjected to detailed history and relevant clinical examination with emphasis on elaborate neurological examination. Informed consent regarding participation into the study was taken from the patients. Patients suspected of suffering from carpal tunnel syndrome were subjected to nerve conduction study. Patients were classified into mild- moderate and severe carpal tunnel syndrome according to clinical and nerve conduction grading.Results: Out of 60 females, 21 were pregnant (35%) and 19 were lactating (31.7%).  The mean age of presentation was 44.6±14.14 years with range from 22 to 63 years. Causes were attributed to Pregnancy (35%) lactation (31.7%), hypothyroidism (18.3%), occupational risk factors (15.85%) and gout (2.4%).Conclusions: Carpal tunnel syndrome has a high incidence in females. Sensory symptoms (paresthesia, numbness and nocturnal pain) were more common than symptoms of motor weakness. Dominant hand involvement was more common.

Dementia of Alzheimer's Type is a common disorder with a massive impact on the quality of life of patients and their caregivers. After age 65 years, the prevalence of dementia increases greatly with age (Evans DA, 1989; Rocca WA, 1986). For this study, thirty Kashmiri Female Bilingual AD ( Moderate-Severe) patients and an equal number of controls matched for age, gender and education were tested in a simple Sentence Translation Task. The study aimed to find out the effect of Alzheimer's disease on the patient's ability to use syntactic information in sentence comprehension and whether the subjects are able to read and translate sentences properly. The results from the Cross Comparison in this study reveal that Mild and Moderate AD patients produce more errors in reading, comprehension and translating sentences than Control group. While as Advanced AD patients show a severe impairment in their ability to process Syntactic information.