A series of copper sulfide (CS) nanoparticles (NPs) were synthesized just by varying the amount of sulfur precursor and have been explored for the first time as a three way...

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In the present paper, we have reported the synthesis and application of polypyrrole (PPy)/Cu(II) nanocomposite as an efficient heterogeneous catalyst for synthesis of 4-aryl-NH-1, 2,3-triazoles. The nanocomposite was prepared via...

: The use of natural and environment friendly energy sources for betterment of the living society has become an active concern in both government and public sector. Due to this, responsible use of global resources has become a growing concern among people. Similarly, in chemical industry especially in pharmaceutical fields, there is constant pressure in reducing hazardous organic solvents and environmentally detrimental laboratory materials. The use of ionic liquids in efficient synthesis of a wide array of fundamentally important structural motifs has gained tremendous importance in the scientific era. In this review, synthesis of two such medicinally relevant moieties, namely, triazole and pyrazole, in green and sustainable ionic liquid have been discussed.

Here an environmentally friendly process has been developed for the synthesis of pyrazole and its derivatives through cycloaddition‐iodination‐Suzuki type reaction by the use of lithium perchlorate as a Lewis acid catalyst. The synthetic pathway involves the synthesis of pyrazoles with various electron donating and electron withdrawing functional groups containing hydrazines and 1,3‐diketones (70‐95% yields); then one step formation of 4‐iodo‐pyrazoles (59% yield) followed by modification via palladium catalyzed Suzuki‐Miyaura cross coupling reaction to obtain the desired biaryls substituted pyrazoles under mild reaction conditions with high efficiency and product purity (53‐70% yields). The biological activity was evaluated through in vitro analysis towards the antimicrobial activities against the growth of Staphylococcus Aureus (for Gram positive) and Pseudomonas Aeruginosa (for Gram negative) with minimum inhibitory concentration (MIC) values ranging from 225 to 850 μg/ml. Molecular docking studies of the compounds into the active site of thymidylate kinase receptor of Pseudomonas Aeruginosa PAO1 revealed notable information on the probable binding interaction.

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A green protocol for the synthesis of a series of 5-amino-1,2,3-triazoles from benzyl cyanide and phenyl azide derivatives catalyzed by the novel bifunctional ionic liquid [DHIM][OH] under microwave irradiation has...