A copper acetate monohydrate catalyzed simple, effective and economic protocol has been developed for the construction of quinazoline derivatives via acceptorless dehydrogenative coupling of easily available 2-aminoaryl methanols and nitriles. The methodology was also highly effective for the synthesis of medicinally important quinolines analogues. The reactions proceeded in presence of KO t Bu in toluene at 110 °C for 5 h without the requirement of inert condition, external additives and ligands.
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