Background
In the global health emergency caused by COVID-19, multiple experts have mandated the use of hand sanitizers as a safety measure from COVID-19. The sale of hand sanitizers has increased many folds. Therefore, when there is such large use of hand sanitizers, it becomes extremely important to study and understand hand sanitizers in a comprehensive manner.
Main body of the abstract
This article starts with the importance of sanitizers as a defence mechanism that is employed by the hand to fight against the coronavirus. This article provides information about history, types, composition, various dosage forms, and marketed formulations of hand sanitizers. The article sheds a detailed light on industrial production techniques for hand sanitizers and also outlines new innovative techniques that were employed by the industry to mass produce hand sanitizers in the wake of the pandemic. The article further dives into a comparison between hand sanitizers and soaps so as to give pros and cons of the use of soap against the use of hand sanitizers. One of the aims of the article is to study the side effects of sanitizers so as to develop a cautious approach while using hand sanitizers and therefore a comprehensive list of side effects of the use of hand sanitizers is given.
Conclusion
The review article finds that hand sanitizers are extremely efficient in fight the virus but along with it, it brings along arrange of risks which are outlined in the article.
Aims: To study force degradation of aspirin and omeprazole simultaneously by RP-HPLC method
Study design: RP-HPLC method was used to measure % degradation.
Place and Duration of Study: Study was carried out at center of excellence, G.I.D.C., vapi-396195, Gujarat, India between June 2019 to march 2020.
Methodology: A force degradation study of aspirin and omeprazole was carried out simultaneously. The drugs were subjected to various degradation conditions like hydrolysis by acid and base, Oxidative degradation, and thermal degradation study.
Results: For acidic condition, the degradation was found to be 32.63 % for aspirin and 61.64 % for omeprazole. For basic condition, the degradation was found to be 10.17 % for aspirin and 4.29 % for omeprazole. By oxidative hydrolysis, the aspirin was degraded by 15.48 % and omeprazole was degraded by 26.38 %. By thermal degradation, 0.37 % degradation was observed for aspirin and 4.32 % degradation for omeprazole.
Conclusion: In this proposed method the retention time for drug is less than 8 min, which is less then available method. For omeprazole, strong degradation was observed in acidic conditions and mild in basic hydrolysis conditions. For aspirin, more degradation was observed in basic conditions than acidic hydrolysis. Both drugs were degraded in oxidative conditions using 3% H2O2. Omeprazole degraded more than aspirin by dry heat degradation. The method was successfully applied for the quantitative determination of both Active Pharmaceutical Ingredients.
An eco-friendly method for quantification of Omeprazole in Pharmaceutical solid dosage form has been developed using Fourier transform infrared spectrophotometry. The proposed method avoids use of solvents which are commonly used for other methods of quantification e.g. Liquid Chromatography, UV spectrophotometry etc. The developed method has been validated for quantification of Omeprazole in marketed formulation as per ICH Q2 R (1) guidelines. The method is based on Beer-lamberts’ law. For the quantification C-O stretch absorption band at 1204 cm−1 was selected which is typically in the range of 1300 – 1000cm-1 in IR spectrum. The linearity of Omeprazole was obtained in the concentration range of 5 – 30mg/g with R2 value of 0.999. The % recovery was calculated with Intra and Inter day precision study.
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