Three new phorbol esters, 12-(2-N-methylaminobenzoyl)-4beta,5,20-trideoxyphorbol-13-acetate (1), 12-(2-N-methylaminobenzoyl)-4alpha,5,20-trideoxyphorbol-13-acetate (2), and 12-(2-N-methylaminobenzoyl)-4alpha, 20-dideoxy-5-hydroxyphorbol-13-acetate (6), together with six known compounds (3-5 and 7-9), were isolated from the fruits of Sapium indicum. The chemical structures of 1, 2, and 6 were elucidated by analysis of their spectroscopic data. Compounds 1-3, 5, and 7-9 exhibited antimycobacterial activity with minimum inhibitory concentrations (MIC) between 3.12 and 200 microg/mL, but compounds 4 and 6 were inactive (MIC >200 microg/mL).
Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-H187 cell line.
A New Triterpenoid Ester from the Fruits of Bruguiera parviflora. -The new lupane caffeoyl ester (I) is isolated together with 5 known compounds from the fruits of Bruguiera parviflora. (I) exhibits antimalarial activity. -(CHUMKAEW, P.; KATO, S.; CHANTRAPROMMA*, K.; Chem. Pharm. Bull. 53 (2005) 1, 95-96; Sch. Sci., Walailak Univ., Nakhon Si Thammarat 80160, Thailand; Eng.) -M. Bohle 33-207
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.