No abstract

The aim of this study was to evaluate the antimalarial efficacy and the acute toxicity of the 80% ethanol extracts of Enantia olivacea, Garcinia punctata and Massularia acuminata stem barks. The in vivo antimalarial efficacy of these extracts was investigated alone or in combination by the 4-day suppressive test. To assess the acute toxicity, mice were treated with a single oral dose of each individual (2,000 mg/kg) and combined extract (≤ 1,200 mg/kg). During 7 days, the animals were observed for any clinical signs of toxicity, changes in body weight and mortality. At 200 mg/kg, Enantia olivacea, Garcinia punctata and Massularia acuminata extracts resulted, respectively, in 57.2 %, 45.3 % and 32.6 % reduction of parasitemia in mice. The combination therapy of Enantia olivacea, Garcinia punctata and Massularia acuminata (50 and 200 mg/kg of each extract) showed increased protection and survival rate associated with a significant delay of recrudescence compared with each monotherapy. No acute toxicity was observed in all the treated mice, and the 50 % lethal dose of the combined extract was assumed to be > 1,200 mg/kg. These results can partly support the use of these three plant parts for the treatment of uncomplicated malaria in Congolese traditional medicine.

Background: It is reported that 20 to 30% of patients are not responders to this treatment (Cardiac Resynchronization Therapy). The reasoning in this merely theoretical paper shows the plausible danger that can be brought by measurements apparatus, in the occurrence the CRT especially when it is sophisticated. Objective: In Physical Cardiochemistry field our overall purpose is to bring a contribution to heart health. It is needful to draw attention for caregivers and manufacturers, especially with respect to the magnetism these apparatuses may exhibit. Methods: The Observation and documentary research are used. It is recalled hereby successively energy metabolism in healthy cardiomyocyte, adaptive energy metabolism of a hypertrophied and insufficient heart, cardiac resynchronization therapy and energy metabolism of the cardiomyocyte with its potential effects on both glucose oxidation and fatty acids oxidation. Results: It is shown a plausible interaction between oxygen magnetic field, paramagnetic by nature, and pacemaker and/or defibrillator electromagnetic field according to the sacral principle of “like dissolves like” with all evil consequences on patients. Conclusion: It will be necessary to evaluate later not only the behavior of the various energetic substrates of a hypertrophied heart as a function of the variation of the magnetic field strength but also the content of the probable substances produced in the presence of a magnetic field and with a potentially harmful effect on cardiac function. Convinced technology has its setbacks, the pacemakers and/or defibrillators manufacturers are invited to a greater rigor, greater caution and sustained care in building these devices. In next publication study of a case (CRT-D), where the diabetes has been observed, will be outlined.

Background: The heart acting analysis leads to necessity of total energy quantization needful for its life from the cellular metabolism (Keith Flack node). This energy is mainly distributed to make possible the cardiac muscle acting (Electrocardiogram) and to circulate the blood in aorta to be ultimately poured out the small circulation in upstream of general circulation, distribution obeying Lusamba diagram. A model has been elaborated to choose a thermodynamic system (KUNYIMA Chart) on which the needful energy of blood flow has been assessed. It stays to quantify the vital energy for the electrification of cardiac muscle (ECG) in order to have a definitive idea on total energy from Keith Flack node. Each heart failure demands energetic knowledge of Keith Flack node and the energetic repartition of ventricles shrinkages. Aim and Objective: Presentation master program in cardiochemistry (new discipline) and Lusamba diagram to scientific world. Methodology: Observation, documentary research and calculations have been used. Results: Physico-chemical and thermoexergetic grounds of heart acting have been published elsewhere and allowed thus to conceive this program. Conclusion: Physical Cardiochemistry (PCC) is therefore a set of physico-chemical and thermoexergetic grounds of heart acting. It backs up the bio-medical sciences and helps in one sense to the comprehension of certain energetic phenomena occurring in the cardiac system. Therefore, this large knowledge will help physicians to efficient prescriptions for an effective energetic and appropriate supplying. It is supposed evidently that future cardiac healing will essentially be energetic.