Despite the successes earned in cataloguing and finding the role of the most of molecular components in living matter, the “biochemical and molecular” perspective, popular in biology, medicine and genetics, is unable to give account for crucial topics as the faculty of living systems to “feel”, to “perceive” what a given stimulus implies (means, indeed) for their survival. Condensed matter physics too, if bounded to a local, short-range, and perturbative approach, fails dramatically. This is also due to the role commonly assigned to water – actually the main constituent of living matter – deemed for long time to be merely chemical (as “solvent” or a reactant/product). Nonetheless, today many evidences show how living matter can be right conceived as a super-structured coherent water-based matrix, suggesting that the characterization of bio(electro)chemical and physical processes undertaken at molecular level in living matter, would let us unable to answer a question like this: what allows an amoeba, moreover without any neurons, to “know” to get closer to a nutrient or escape away from a toxin? I propose that to pursue such a fundamental inquiry it’s necessary an essentially relational approach, that is: to consider the living being at its grounding as the outcome of a physical history of relationships where symmetry-breakings, dissipation and coherence yield the emergence of the living state of matter, conceivable only as a time-dependent open process, and not as a portraited “body”. The effective tools to build up such an approach may be retrieved in far-from-equilibrium thermodynamics (TD), symmetry-breakings and gauge-fields theory, science of complexity, within the framework of a Quantum Field Theory. Indeed, within a field-view of matter, and of water especially, as it has been developed by a Quantum Electrodynamic (QED) description of condensed matter, it’s possible to give account for a physical basis too such an epistemologically elusive, though crucial, feature of living systems (i.e.: perception and meaning). The emerging landscape allows some important meditations about adaptation, evolution, ecodynamics, and about different conceptions of complexity and “information” in living realm. Furthermore, some neuroscientific themes like consciousness, qualia and their links to artificial intelligence could be supplied with due insights.

Background: isosbestic (equal absorption) points in the IR and NIR spectra of liquid water are a well-known feature and they witness the existence of two populations of oscillators in the probed system. Despite it is a well-known experimental fact, in the mainstream molecular dynamics approach the proposed theoretical explanations for it are not able to elucidate which is the physical reason why such a "cut-off frequency" (at the isosbestic point) does exist. Methods: We investigate pure Milli-Q water on increasing the temperature in the vis-NIR range (400-2500 nm). We specifically payed attention to the first overtone region (1300-1600 nm) of the OH-bond stretching-mode where an isosbestic point has been observed. Results: A second derivative analysis clearly shows two modes, which can be assigned to water molecules involved in different "hydrogen bonding" configurations whose relative abundance is controlled by the temperature. We have also observed that the ratio of these modes follows a van't Hoff behavior supporting that their energy difference (energy gap) is independent on the temperature. Furthermore, a log-log plot shows a scale invariance of the population ratio with respect to the perturbation (temperature), confirming the existence of a long-range correlated dynamics in the liquid. Conclusions: We show that the two phases differences between energy and entropy estimated from the experimental data can be compared with the prediction of Quantum Electro Dynamics (QED) showing a remarkable agreement.

Introduction. Recalcitrant skin ulcers are a major burden in elderly patients. Specifically, chronic wounds result in significant morbidity and mortality and have a profound economic impact. Pulsed electromagnetic fields (PEMFs) have proved to be a promising therapy for wound healing. Here we describe the first reported case of an innovative PEMF therapy, Emysimmetric Bilateral Stimulation (EBS), used to successfully treat refractory skin ulcers in two elderly and fragile patients. Case Presentation. Two elderly patients developed multiple chronic skin ulcerations. Despite appropriate treatment, the ulcers showed little improvement and the risk of amputation was high. Both patients underwent daily EBS therapy and standard dressing. After few weeks of treatment, major improvements were observed and all ulcers had healed. Conclusion. In patients with refractory ulceration, EBS therapy may be of real benefit in terms of faster healing. This case supports the supportive role for PEMFs in the treatment of skin ulceration in diabetes and is suggestive of a potential benefit of EBS in this clinical condition.

In this article I present the extracts and summary of heuristic and speculative observations on various aspects I feel are problematic in the practice of modern physics, the definitions and methods of which are the premise for the whole of Science. The illustrations will be fully developed in a later, more extensive and in-depth work in which some theoretical solutions will also be put forward; therefore in the interests of brevity all assertions will not be demonstrated fully in this article. I will initially discuss the problem with thinking of Reality as basically being made up of ontologically autonomous "parts"; I will recall how the existence of the vacuum is demonstrated through the thermodynamic experiments about heat capacities run by W. Nernst and the experiments of W. Lamb and H. Casimir (static and dynamic); the vacuum will be defined as an object that precedes matter and space, and actually illustrated as an evolving (becoming) singularity, which all existence draws from; the non-isolability of the autonomous entity will be substantiated further by the uncertainty demonstrated as intrinsically following on from phase space quantisation, and not only as an algebraic requirement of quantum formalism. Once the inconsistency of the isolable entity has been demonstrated, the ontological supremacy of relationships in a perspective close to ontic structural realism will be considered; finally, issues relating to the usual idea of "information" in the scientific domain (in thermodynamics, informatics, and telecommunications) will be discussed fairly briefly, and its inadequacy in pooling knowledge. I will then touch on what is meant by living information as the basis for Reality and how it can be discussed consistently in terms of a self-implementing subject. It should be stressed that these topics are dealt with more extensively (along with other important subjects excluded here for reasons of space) in a complete work.

Background and aimsIn the last decade, the development of different methods of brain stimulation by electromagnetic fields (EMF) provides a promising therapeutic tool for subjects with impaired cognitive functions. Emisymmetric bilateral stimulation (EBS) is a novel and innovative EMF brain stimulation, whose working principle is to introduce very weak noise-like stimuli through EMF to trigger self-arrangements in the cortex of treated subjects, thereby improving cognitive faculties. The aim of this pilot study was to investigate in patients with cognitive impairment the effectiveness of EBS treatment with respect to global cognitive function, episodic memory, and executive functions.MethodsFourteen patients with cognitive decline (six with mild cognitive impairment and eight with Alzheimer’s disease) underwent three EBS applications per week to both the cerebral cortex and auricular-specific sites for a total of 5 weeks. At baseline, after 2 weeks and 5 weeks, a neuropsychological assessment was performed through mini–mental state examination, free and cued selective reminding tests, and trail making test. As secondary outcomes, changes in behavior, functionality, and quality of life were also evaluated.ResultsAfter 5 weeks of standardized EBS therapy, significant improvements were observed in all neurocognitive assessments. Mini–mental state examination score significantly increased from baseline to end treatment (+3.19, P=0.002). Assessment of episodic memory showed an improvement both in immediate and delayed recalls (immediate recall =+7.57, P=0.003; delayed recall =+4.78, P<0.001). Executive functions significantly improved from baseline to end stimulation (trail making test A −53.35 seconds; P=0.001). Of note, behavioral disorders assessed through neuropsychiatric inventory significantly decreased (−28.78, P<0.001). The analysis concerning the Alzheimer’s disease and mild cognitive impairment group confirmed a significant improvement of cognitive functions and behavior after EBS treatment.ConclusionThis pilot study has shown EBS to be a promising, effective, and safe tool to treat cognitive impairment, in addition to the drugs presently available. Further investigations and controlled clinical trials are warranted.

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