within collagenous stroma. The spindle cells have uniform tapered nuclei and ill defined cytoplasm. Only one mitotic figure was identified. No lymphovascular or perineural invasion was seen. Immunohistochemistry expressed markers of smooth muscle actin (SMA) and S-100. Inhibin showed weak positive staining. The tumour cells were negative for CD99, CD34, desmin and broad spectrum cytokeratin. The histopathology and immunohistochemistry was consistent with a myoid gonadal stromal tumour and this is distinctly different from other sex cord-stromal tumours. Reference 1. Chia-Sui K, Ulbright TM. Myoid gonadal stromal tumour. A clinicopathologic study of three cases of a distinctive testicular tumour. Am J Clin Pathol 2014; 142: 675-82.
melanoma is rare. The most common combinations are BCC with squamous cell carcinoma, BCC with seborrhoeic keratosis and BCC with neurofibroma. The prognosis of each tumour must be considered separately. Melanoma colonising the BCC should still be considered as 'in situ' and not as invasive if no atypical melanocyte is found outside the BCC nests. Here we report two cases of BCC associated with melanoma. In the first case, BCC was associated with melanoma in situ. The atypical melanocytes were confined to the nests of basal cell carcinoma. In the second case, BCC was admixed with invasive melanoma. In this case, the atypical melanocytes were present within the BCC nests, but were also identified within the dermis, outside the nests of BCC. The presence of two coexisting neoplasms was confirmed on immunohistochemistry. In addition, we compared these cases with a pigmented BCC showing benign melanocytes colonising the tumour cell nests.The key diagnostic features of this collision tumour, its pathogenesis, differential diagnosis and its prognosis will be discussed.Injection into the subcutaneous tissues of the penis for augmentation has been practiced throughout history. With the recognition of complications and sequalae the practice has died out in the developed world. However, it is still practiced in parts of Europe and Asia today, though the extent of the practice is unknown, and today's published literature may only scratch the surface. We report a case of mineral oil induced sclerosing lipogranuloma of the penis in a 55-year-old male from Papua New Guinea who presented with a mass involving the penile prepuce and shaft skin. This case demonstrates the diagnostic challenges and interesting pathology seen in developing countries. The treatment of choice is radical excision of the lesions with skin grafts.Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare, benign, vascular lesion with characteristic histological features. Often an incidental finding, full excision of the lesion has been shown to be curative. We describe a case of SANT in a 35-year-old woman who presented with a purported splenic haemangioma with atypical imaging features including an uncharacteristic enlargement over a two-year period. Gross examination of the splenectomy specimen revealed a circumscribed 42 mm white, lobulated mass with prominent central sclerosis and dilated vascular spaces at the periphery. Histological examination showed a hyalinised lesion with a nodular architecture imparted by nodules of small capillary channels with red cell extravasation, and scattered admixed chronic inflammatory cells. A rare lesion of indeterminate aetiology, SANT remains a curiosity and an essential diagnostic consideration among vascular lesions of the spleen with features not typical of haemangioma.There are currently 139 international brain bank facilities which collect, store and provide nervous system samples for research purposes. The human post-mortem brains within these brain banks have underpinned the basic understa...
examination cannot comprehensively assess the molecular heterogeneity in the tumour microenvironment. We aim to capture tissue morphology and single cell protein expression of cancer and immune cells within intact tissue sections of stage III colorectal tumours from 11 patients. Methods: Using Hyperion Image Mass Cytometry (IMC), we simultaneously profiled 16 protein markers from FFPE samples, including cancer (Ki-67, p53) and immune (CD3, CD4, CD8a, CD45RO, CD20, CD68, Granzyme B) cell markers. We integrated this with matched histopathological imaging and wholeexome-sequencing data. Results: We identified seven cancer, immune and stromal cell types and preserved their spatial organisation within the microenvironment. These cell types were validated on matched H&E histopathology. We found significant interactions of cancer cells with NK-cells and B-cells. Furthermore, we found that tumours with 17p deletion had significantly fewer NK-cells. Conclusion: Using IMC to acquire rich spatial data at single-cell resolution enabled us to assess the heterogeneity of tumour tissue by defining cell types, immune infiltration, and cancer-immune cell interaction within intact tissue sections. Integration of this data with H&E images could assist pathologists in cancer diagnosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.