Myoid gonadal stromal tumour: A case report

Abstract

melanoma is rare. The most common combinations are BCC with squamous cell carcinoma, BCC with seborrhoeic keratosis and BCC with neurofibroma. The prognosis of each tumour must be considered separately. Melanoma colonising the BCC should still be considered as 'in situ' and not as invasive if no atypical melanocyte is found outside the BCC nests. Here we report two cases of BCC associated with melanoma. In the first case, BCC was associated with melanoma in situ. The atypical melanocytes were confined to the nests of basal cell carcinoma. In the second case, BCC was admixed with invasive melanoma. In this case, the atypical melanocytes were present within the BCC nests, but were also identified within the dermis, outside the nests of BCC. The presence of two coexisting neoplasms was confirmed on immunohistochemistry. In addition, we compared these cases with a pigmented BCC showing benign melanocytes colonising the tumour cell nests.The key diagnostic features of this collision tumour, its pathogenesis, differential diagnosis and its prognosis will be discussed.Injection into the subcutaneous tissues of the penis for augmentation has been practiced throughout history. With the recognition of complications and sequalae the practice has died out in the developed world. However, it is still practiced in parts of Europe and Asia today, though the extent of the practice is unknown, and today's published literature may only scratch the surface. We report a case of mineral oil induced sclerosing lipogranuloma of the penis in a 55-year-old male from Papua New Guinea who presented with a mass involving the penile prepuce and shaft skin. This case demonstrates the diagnostic challenges and interesting pathology seen in developing countries. The treatment of choice is radical excision of the lesions with skin grafts.Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare, benign, vascular lesion with characteristic histological features. Often an incidental finding, full excision of the lesion has been shown to be curative. We describe a case of SANT in a 35-year-old woman who presented with a purported splenic haemangioma with atypical imaging features including an uncharacteristic enlargement over a two-year period. Gross examination of the splenectomy specimen revealed a circumscribed 42 mm white, lobulated mass with prominent central sclerosis and dilated vascular spaces at the periphery. Histological examination showed a hyalinised lesion with a nodular architecture imparted by nodules of small capillary channels with red cell extravasation, and scattered admixed chronic inflammatory cells. A rare lesion of indeterminate aetiology, SANT remains a curiosity and an essential diagnostic consideration among vascular lesions of the spleen with features not typical of haemangioma.There are currently 139 international brain bank facilities which collect, store and provide nervous system samples for research purposes. The human post-mortem brains within these brain banks have underpinned the basic understa...