Therapies based on the autologous grafting of adult mesenchymal stem cells (MSC) are known to effectively accelerate the skin's healing and the regenerative processes of mesenchymal tissues. [1][2][3] Regenerative medicine mostly uses adipose-derived stem cells (ADSC), which are pluripotent adult progenitor cells derived from embryonic connective tissue. 3,4 Adipose tissue is found throughout the adult human body in bone marrow, adipose tissue, muscle, and dermis. 3,4 ADSC share similar characteristics with bone marrow mesenchymal cells. Still, they have some advantages, including their easy availability and harvesting through a less invasive surgical procedure. 3,[5][6][7] Compared with the bone marrow, the adipose tissue is richer in adult MSCs and stromal components (the stromal vascular fraction [SVF]). 6,7 ADSC have the potential to differentiate into mesodermal cells (e.g. adipocytes, cartilage, bone, and skeletal muscle) and cells of non-mesodermal lineage (e.g. neurons, cardiomyocytes, and vascular endothelial cells). 3,6,7 Moreover, ADSC can release trophic and soluble factors with anti-fibrotic, anti-apoptotic, and pro-angiogenic properties that provide ADSC with regenerative and immune-modulatory activities. 3,7 The ADSCs regenerative and anti-inflammatory properties currently find therapeutic applications in various medical fields including, but not limited to, reconstructive and esthetic surgery
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