Aim: This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.
Materials and methods:The 2 main experimental endpoints at which the serum Na levels were evaluated was the 60 th reperfusion min (for the groups A, C and E) and the 120 th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D after Epo administration; whereas groups E and F after the L administration.
Results:The first preliminary study of Epo presented a non significant hyponatremic effect by 0.11% ± 0.38% (p-value = 0.7531). The second preliminary study of U-74389G presented a non significant hyponatremic effect by 0.32% ± 0.36% (p-value = 0.3693). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that L is 2.74914-fold [2.74424-2.754048] more hyponatremic than Epo (p-value = 0.0000).
Conclusions:The anti-oxidant capacities of U-74389G ascribe 2.74914-fold more hyponatremic effects than Epo (p-value = 0.0000).
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