Aim: This study co-evaluated the 4 quoted histologic variables after the lazaroid U-74389G (L) drug administration. The calculation was based on the results of 2 preliminary studies, each one evaluating two respective histologic variables of Endometrial Edema (EE) and Uterus Inflammation (UI) or Endometrial Karyorrhexis (EK) and Uterus Congestion (UC); in an induced ischemia reperfusion animal experiment.
Materials and methods: The 2 main experimental endpoints at which the EE, UI and EK, UC scores were evaluated was the 60th reperfusion min (for the groups A and C) and the 120th reperfusion min (for the groups B and D). Specially, the groups A and B were processed without drugs, whereas the groups C and D after L administration.
Results: The first preliminary study showed that L has a non-significant recessing potency for EE and UI histologic parameters at the “without lesions” grade 0.2636364±0.14594051 (p-values=0.0698). The second preliminary study showed that L has a non-significant recessing potency for EK and UC histologic parameters at the “without lesions” grade 0.1253529 ± 0.08529668 (p-values=0.1373) since they were co-evaluated together. These 2 studies were co-evaluated since they came from the same experimental setting. This study co-evaluated the combined diagnostic values of the four variables together.
Conclusion: L administration and reperfusion time together non-significantly accentuated the 4 histologic variables within the “without lesions alterations” score 0.0758471 [-0.1464624 - +0.2981566] (p-value=0.4940).
Aim: This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.
Materials and methods:The 2 main experimental endpoints at which the serum Na levels were evaluated was the 60 th reperfusion min (for the groups A, C and E) and the 120 th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D after Epo administration; whereas groups E and F after the L administration.
Results:The first preliminary study of Epo presented a non significant hyponatremic effect by 0.11% ± 0.38% (p-value = 0.7531). The second preliminary study of U-74389G presented a non significant hyponatremic effect by 0.32% ± 0.36% (p-value = 0.3693). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that L is 2.74914-fold [2.74424-2.754048] more hyponatremic than Epo (p-value = 0.0000).
Conclusions:The anti-oxidant capacities of U-74389G ascribe 2.74914-fold more hyponatremic effects than Epo (p-value = 0.0000).
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