Preoperative NLR and PLR were found to be correlated to unfavorable histopathologic features of cervical cancer. The preoperative NLR, but not PLR, may be used as a potential and easy biomarker for survival prognosis in patients with cervical cancer receiving initial radical hysterectomy with pelvic lymphadenectomy.

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In an urban subway network, a synchronized and optimized timetable can provide a good service to all passengers. Therefore, the timetable is typically the most important factor for an operator. This study builds a time-dependent passenger demand-driven timetable synchronization and optimization (TDTSO) model as a mixed-integer programming model to minimize passenger total travel time in an urban subway network by adjusting departure times, running times, stopping times, and headways of all trains on each line. To solve the model, a binary variable determination (BVD) method is developed to calculate the binary variables of the TDTSO model, and a genetic algorithm based on the BVD method is proposed. The proposed TDTSO model is applied to the Beijing subway network in a case study. Several performance indicators are presented to verify the efficiency of the proposed model. The results can provide the operator of an urban subway network with additional options to produce a synchronized and optimized timetable for real-world situations.