Preoperative Neutrophil-Lymphocyte Ratio Before Platelet-Lymphocyte Ratio Predicts Clinical Outcome in Patients With Cervical Cancer Treated With Initial Radical Surgery

Zhang, Yu; Wang, Le; Liu, Yunduo; Wang, Shuxiang; Shang, Pan; Gao, Ya; Chen, Xiuwei

doi:10.1097/igc.0000000000000219

Cited by 68 publications

(80 citation statements)

References 27 publications

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“…In addition, treatment modality (CCRT vs. RT) was also reported to be an impact prognostic factor, as CCRT had a higher rate of success than RT alone [12]. The present study showed that the NLR before treatment was significantly related to the outcomes of radiation for the uterine cervical cancer, and supported results shown by Lee et al [9] and Zhang et al [10]. In addition, the present study showed that a low NLR (less than 2.5) was significantly associated with a CR and longer PFS and longer OS in comparison to a high NLR (2.5 and over).…”

Section: Discussionsupporting

confidence: 81%

“…The fact that a high NLR is a factor for a poor prognosis after surgery or after chemotherapy has been reported in relation to various types of carcinomas [3][4][5][6][7][8][9][10]. Looking specifically at cervical cancer, Lee et al.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the pretreatment NLR predicts survival in epithelial ovarian cancer [8] and uterine cervical cancer [9,10]. However, the NLR was not a predictive factor in patients with uterine cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy [11].…”

Section: Introductionmentioning

confidence: 99%

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The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer

et al. 2015

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Objective: The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment of cervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT).Methods: Fifty-six patients with squamous cell carcinoma (SCC) of the uterine cervix who underwent RT or CCRT from 2005 to 2013 at this Hospital were retrospectively identified using electronic databases.Patients were divided into a high NLR group (≥ 2.5) and a low NLR group (< 2.5). The efficacy of RT and CCRT in the two groups was compared.Result: Of the 56 patients, 35 were in the high NLR group and 21 were in the low NLR group. In comparison to a high NLR, a low NLR was significantly associated with a complete response (P < 0.001).When cancer was divided into stages I/II and III/IV, patients with a low NLR had a significantly better therapeutic outcome than those with a high NLR (P < 0.05). Multivariate analysis showed that only the NLR was a significant prognostic factor for progression-free survival (PFS). Patients with a high NLR had a significantly shorter PFS and overall survival than those with a low NLR.Conclusion: Results showed that a low NLR before treatment can predict a good response to RT or CCRT by all stages of uterine cervical cancer. The NLR may be a promising parameter on which to base the choice of a therapeutic strategy to treat SCC of the uterine cervix.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer

et al. 2015

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“…Despite inconsistent results, these markers have been reported to have significant diagnostic and prognostic value in a wide variety of cancers. The MLR has been suggested to be associated with survival in patients with malignant lymphomas and many solid tumors, such as head and neck, breast [14], lung, esophageal, gastric, colorectal [15], [16], pancreatic, bladder [6], and cervical cancers [5]. A high MLR was associated with poor OS in previous reports, and the MLR can be considered to be a potential surrogate biomarker in various cancers.…”

Section: Discussionmentioning

confidence: 91%

“…Kawata et al have reported that lymphocyte infiltration around the tumor is associated with a better prognosis in HCC [5], whereas the presence of neutrophils in the tumor stroma is associated with a poor prognosis [6]. Likewise, the neutrophil-to-lymphocyte ratio (NLR), a predictor of inflammatory status, has been shown to be an effective prognostic marker for many solid tumors [7], [8], [9], [10], [11], [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer

Xiang

Zhou

Xing

et al. 2017

Translational Oncology

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PURPOSE: The monocyte-to-lymphocyte ratio (MLR) has been shown to be associated with the prognosis of various solid tumors. This study sought to evaluate the important value of the MLR in ovarian cancer patients. METHODS: A total of 133 ovarian cancer patients and 43 normal controls were retrospectively reviewed. The patients' demographics were analyzed along with clinical and pathologic data. The counts of peripheral neutrophils, lymphocytes, monocytes, and platelets were collected and used to calculate the MLR, neutrophil-to-lymphocyte ratio (NLR). and platelet-to-lymphocyte ratio (PLR). The optimal cutoff value of the MLR was determined by using receiver operating characteristic curve analysis. We compared the MLR, NLR, and PLR between ovarian cancer and normal control patients and among patients with different stages and different grades, as well as between patients with lymph node metastasis and non–lymph node metastasis. We then investigated the value of the MLR in predicting the stage, grade, and lymph node positivity by using logistic regression. The impact of the MLR on overall survival (OS) was calculated by Kaplan-Meier method and compared by log-rank test. RESULTS: Statistically significant differences in the MLR were observed between ovarian cancer patients and normal controls. However, no difference was found for the NLR and PLR. Highly significant differences in the MLR were found among patients with different stages (stage I-II and stage III-IV), grades (G1 and >G1), and lymph node metastasis status. The MLR was a significant and independent risk factor for lymph node metastasis, as determined by logistic regression. The optimal cutoff value of the MLR was 0.23. We also classified the data according to tumor markers (CA125, CA199, HE4, AFP, and CEA) and conventional coagulation parameters (International Normalized Ratio [INR] and fibrinogen). Highly significant differences in CA125, CA199, HE4, INR, fibrinogen levels, and lactate dehydrogenase were found between the low-MLR group (MLR ≤ 0.23) and the high-MLR group (MLR > 0.23). Correspondingly, dramatic differences were observed between the two groups in OS. CONCLUSION: Our results show that the peripheral blood MLR before surgery could be a significant predictor of advanced stages, advanced pathologic grades, and positive lymphatic metastasis in ovarian cancer patients.

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Predictive significance of lymphocyte level and neutrophil‐to‐lymphocyte ratio values during radiotherapy in cervical cancer treatment

Zhao

Gao

et al. 2023

Cancer Medicine

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ObjectiveThe objective of this research was to analyze the prognostic significance of the minimum count of lymphocytes (LY) and the corresponding ratio of neutrophil‐to‐lymphocyte (NLR) in cervical cancer (CC) patients receiving radiotherapy.MethodsWe retrospectively collected data from 202 CC patients who received concurrent chemoradiotherapy or radiotherapy alone at our hospital. Statistical methods including the Kaplan–Meier method, log‐rank test and the Cox proportional hazards model were included to examine survival differences and identify independent factors that may affect overall survival (OS) and progression‐free survival (PFS).ResultsThe research enrolled a total of 202 patients. Patients with higher LY levels and lower NLR values during radiotherapy had significantly better survival prognosis than those with lower LY levels and higher NLR values. Multivariate COX regression analysis revealed that FIGO stage I, pathological types of SqCC, absence of lymph node metastasis, concurrent chemoradiotherapy, higher LY levels during radiotherapy, and lower NLR values before radiotherapy were independently associated with poorer PFS. Similarly, FIGO stage I, absence of lymph node metastasis and lower NLR values during and before radiotherapy were independently linked with poorer OS.ConclusionMinimum LY value and its corresponding NLR during radiotherapy serve as prognostic factors for CC.

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Preoperative Neutrophil-Lymphocyte Ratio Before Platelet-Lymphocyte Ratio Predicts Clinical Outcome in Patients With Cervical Cancer Treated With Initial Radical Surgery

Cited by 68 publications

References 27 publications

The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer

The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer

Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer

Predictive significance of lymphocyte level and neutrophil‐to‐lymphocyte ratio values during radiotherapy in cervical cancer treatment

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