A facile stereoselective approach for the total syntheses of (R)strongylodiols A, B, C and D is described. A chiron approach has been followed wherein the stereochemistry at the chiral center is fixed and a methodology of base induced elimination of b-alkoxy chloride to get the chiral propargyl alcohol is employed. A key intermediate synthesized from commercially available (-)-diethyl D-tartrate has been utilized for the total syntheses of all the four titled compounds.
The stereoselective total synthesis of strongylodiol H and I has been accomplished. The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene–yne–one employing CBS as a catalyst and a Cadiot–Chodkiewicz coupling reaction as the key reaction steps. A common aldehyde intermediate has been used for the synthesis of both strongylodiols.
A Convergent Approach for the Total Synthesis of the α-Glucosidase Inhibitor (-)-Panaxjapyne-C. -The asymmetric total synthesis of (-)-panaxjapyne-C (I) unequivocally demonstrates that the natural product is the enantiomer of the synthesized product. -(REDDY, A. S.; GANGADHAR, P.; SRIHARI*, P.; Tetrahedron: Asymmetry 24 (2013) 23, 1524-1530, http://dx.
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