“…The biological properties include antibacterial, anticancer, antiviral, enzyme‐inhibitory, sedative and neuritogenic activities . Our own interest in this class of compounds in synthetic aspect has led to the accomplishment of the total syntheses of diacetylenic polyol natural products oploxyne A, B, panaxjapyne C, petrosiol A, D and E(Figure ) . Strongylodiols A−D, isolated from the Okinawan marine sponge of the genus Strongylophora are the fist examples of long‐chain acetylene alcohols which exists as an enantiomeric mixture with a different ratio (strongylodiol A (91:9), stronglylodiol B (97:3), strongylodiol C (84:16) and strongylodiol D (95:5) with the major compound having R configuration in all the four molecules.…”